{"id":4520,"date":"2023-02-19T18:08:37","date_gmt":"2023-02-19T18:08:37","guid":{"rendered":"https:\/\/neuropediatoolbox.org\/?p=4520"},"modified":"2026-06-22T16:28:59","modified_gmt":"2026-06-22T16:28:59","slug":"trayectorias-de-desarrollo-de-las-cln","status":"publish","type":"post","link":"https:\/\/neuropediatoolkit.org\/de\/trayectorias-de-desarrollo-de-las-cln\/","title":{"rendered":"Trayectorias de desarrollo de las CLN."},"content":{"rendered":"<h2 class=\"wp-block-heading\">Lipofuscinosis Neuronales Ceroideas (CLN): Trayectorias de Desarrollo<\/h2>\n\n\n\n<p>Las lipofuscinosis neuronales ceroideas (CLN), com\u00fanmente denominadas enfermedad de Batten, agrupan un conjunto de trastornos neurodegenerativos raros de base lisosomal caracterizados por la acumulaci\u00f3n intralisosomal de material ceroide lipofuscina fluorescente.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Trayectoria Com\u00fan de los S\u00edntomas<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n    <li>P\u00e9rdida progresiva y r\u00e1pida de la agudeza visual que conduce a ceguera (a menudo el primer signo).<\/li>\n    <li>Crisis epil\u00e9pticas miocl\u00f3nicas y focales refractarias al tratamiento farmacol\u00f3gico.<\/li>\n    <li>Regresi\u00f3n progresiva de los hitos cognitivos (demencia) y motores.<\/li>\n    <li>Deterioro motor generalizado con espasticidad profunda y fallecimiento prematuro.<\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Lipofuscinosis Neuronales Ceroideas (CLN): Trayectorias de Desarrollo Las lipofuscinosis neuronales ceroideas (CLN), com\u00fanmente denominadas enfermedad de Batten, agrupan un conjunto de trastornos neurodegenerativos raros de base lisosomal caracterizados por la acumulaci\u00f3n intralisosomal de material ceroide lipofuscina fluorescente. Trayectoria Com\u00fan de los S\u00edntomas P\u00e9rdida progresiva y r\u00e1pida de la agudeza visual que conduce a ceguera (a &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/neuropediatoolkit.org\/de\/trayectorias-de-desarrollo-de-las-cln\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> \u00abTrayectorias de desarrollo de las CLN.\u00bb<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":4535,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[49],"tags":[],"class_list":["post-4520","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-neurodegenerativas","entry"],"_links":{"self":[{"href":"https:\/\/neuropediatoolkit.org\/de\/wp-json\/wp\/v2\/posts\/4520","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/neuropediatoolkit.org\/de\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/neuropediatoolkit.org\/de\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/de\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/de\/wp-json\/wp\/v2\/comments?post=4520"}],"version-history":[{"count":2,"href":"https:\/\/neuropediatoolkit.org\/de\/wp-json\/wp\/v2\/posts\/4520\/revisions"}],"predecessor-version":[{"id":8293,"href":"https:\/\/neuropediatoolkit.org\/de\/wp-json\/wp\/v2\/posts\/4520\/revisions\/8293"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/de\/wp-json\/wp\/v2\/media\/4535"}],"wp:attachment":[{"href":"https:\/\/neuropediatoolkit.org\/de\/wp-json\/wp\/v2\/media?parent=4520"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/de\/wp-json\/wp\/v2\/categories?post=4520"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/de\/wp-json\/wp\/v2\/tags?post=4520"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}