{"id":3485,"date":"2022-11-01T18:02:41","date_gmt":"2022-11-01T18:02:41","guid":{"rendered":"https:\/\/neuropediatoolbox.org\/?p=3485"},"modified":"2023-12-29T18:37:33","modified_gmt":"2023-12-29T18:37:33","slug":"consanguinidad","status":"publish","type":"post","link":"https:\/\/neuropediatoolkit.org\/en\/consanguinidad\/","title":{"rendered":"Consanguinity"},"content":{"rendered":"\n

La consanguinidad<\/a> es el grado de relaci\u00f3n de sangre entre dos personas (parentesco). Hay diversos grados de consanguinidad. Es un factor de riesgo de enfermedades gen\u00e9ticas, en particular las autos\u00f3mico recesivas <\/a>(\u00bfcuando sospechar una metabolopat\u00eda<\/a>, sobretodo, aquellas que tienen tratamiento curativo<\/a>?). <\/p>\n\n\n\n

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Coeficiente de consanguinidad.<\/div><\/summary>
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Existe un coeficiente de endogamia (coefficient of inbreeding and coefficient of relationship<\/a>), que permite calcular la probabilidad de homocigosis en funci\u00f3n de la ascendencia, o inferir la presencia de consanguinidad a partir del grado de homocigosis, que puede ser identificado en los SNP arrays (runs of homocigosity). Esto puede dar lugar al desenmascaramiento de relaciones incestuosas y de abuso.<\/p>\n\n\n

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1.<\/div>
Schaaf C, Scott D, Wiszniewska J, Beaudet A. Identification of incestuous parental relationships by SNP-based DNA microarrays. The Lancet [Internet]. 2011 [cited 2021 Apr 18];377(9765):555\u20136. Available from: https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0140673611602018<\/a><\/div>\n <\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n\n\n\n\n\n
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Paises con m\u00e1s consanguinidad. <\/div><\/summary>
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La consanguinidad es mayor en aquellos pa\u00edses que practican la endogamia<\/a>. El resultado es un aumento de la homocigosis, y como consecuencia, la mayor prevalencia de enfermedades autos\u00f3mico recesivas<\/a>.<\/p>\n\n\n\n

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Los tramos de homocigosidad (regions of homocigosity, ROH) son el resultado gen\u00e9tico de la consanguinidad, y pueden ser estudiados mediante t\u00e9cnicas gen\u00e9ticas como el array de SNP. El coeficiente de endogamia se correlaciona directamente con la cantidad de tramos de homocigosidad de un genoma. <\/p>\n\n\n\n

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Sund KL, Zimmerman SL, Thomas C, Mitchell AL, Prada CE, Grote L, et al. Regions of homozygosity identified by SNP microarray analysis aid in the diagnosis of autosomal recessive disease and incidentally detect parental blood relationships. Genet Med [Internet]. 2013 Enero [cited 2016 Sept 29];15(1):70\u20138. Available from: http:\/\/www.nature.com\/gim\/journal\/v15\/n1\/full\/gim201294a.html<\/a><\/div>\n <\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n\n\n<\/div><\/details>\n\n\n\n
Consanguinidad en las familias reales europeas. <\/div><\/summary>
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Alvarez G, Ceballos FC, Quinteiro C. The Role of Inbreeding in the Extinction of a European Royal Dynasty. PLoS One [Internet]. 2009 Apr 15 [cited 2023 July 17];4(4):e5174. Available from: https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2664480\/<\/a><\/div>\n <\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n\n\n<\/div><\/details>\n\n\n\n
Efecto fundador.<\/a><\/div><\/summary>
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https:\/\/www.nature.com\/articles\/nrg.2017.109<\/a><\/p>\n<\/div><\/details>\n<\/div>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

La consanguinidad es el grado de relaci\u00f3n de sangre entre dos personas (parentesco). Hay diversos grados de consanguinidad. Es un factor de riesgo de enfermedades gen\u00e9ticas, en particular las autos\u00f3mico recesivas (\u00bfcuando sospechar una metabolopat\u00eda, sobretodo, aquellas que tienen tratamiento curativo?).<\/p>","protected":false},"author":1,"featured_media":3487,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[44,10],"tags":[],"class_list":["post-3485","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-consejo-genetico-y-herencia","category-neurogenetica","entry"],"_links":{"self":[{"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/posts\/3485","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/comments?post=3485"}],"version-history":[{"count":11,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/posts\/3485\/revisions"}],"predecessor-version":[{"id":7093,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/posts\/3485\/revisions\/7093"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/media\/3487"}],"wp:attachment":[{"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/media?parent=3485"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/categories?post=3485"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/tags?post=3485"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}