{"id":3561,"date":"2022-11-03T19:07:02","date_gmt":"2022-11-03T19:07:02","guid":{"rendered":"https:\/\/neuropediatoolbox.org\/?p=3561"},"modified":"2022-11-03T19:16:08","modified_gmt":"2022-11-03T19:16:08","slug":"oligonucleotidos-antisentido","status":"publish","type":"post","link":"https:\/\/neuropediatoolkit.org\/en\/oligonucleotidos-antisentido\/","title":{"rendered":"Antisense oligonucleotides."},"content":{"rendered":"\n<p>Los <a href=\"https:\/\/es.wikipedia.org\/wiki\/Oligonucle%C3%B3tido_antisentido\">oligonucle\u00f3tidos antisentido<\/a> son la primera terapia g\u00e9nica (en realidad <a href=\"https:\/\/en.wikipedia.org\/wiki\/Antisense_therapy\">terapia RNA antisentido<\/a>, ya que no modifican el c\u00f3digo gen\u00e9tico) disponible en el mercado para el tratamiento de enfermedades neurogen\u00e9ticas. Se basan en la t\u00e9cnica del <a href=\"https:\/\/en.wikipedia.org\/wiki\/Exon_skipping\">salto del ex\u00f3n<\/a> (Duchenne) o de la inclusi\u00f3n del ex\u00f3n (AME). Pr\u00f3ximamente estar\u00e1 disponible tambi\u00e9n tratamiento para la distrofia miot\u00f3nica de Steinert. <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/es.wikipedia.org\/wiki\/Nusinersen\">Nusinersen <\/a>(<a href=\"https:\/\/www.spinraza.com\/\">Spinraza<\/a>). <\/li>\n\n\n\n<li><a href=\"https:\/\/es.wikipedia.org\/wiki\/Eteplirsen\">Eteplirsen <\/a>(<a href=\"https:\/\/www.exondys51.com\/\">Exondys51<\/a>). <\/li>\n\n\n\n<li>Golodirsen (<a href=\"https:\/\/www.vyondys53.com\/index-es.html\">Vyondys 53<\/a>). <\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image size-full\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"888\" src=\"http:\/\/neuropediaclinic.com\/wp-content\/uploads\/2022\/11\/imagen-36.png\" alt=\"\" class=\"wp-image-3562\" srcset=\"https:\/\/neuropediatoolkit.org\/wp-content\/uploads\/2022\/11\/imagen-36.png 1024w, https:\/\/neuropediatoolkit.org\/wp-content\/uploads\/2022\/11\/imagen-36-300x260.png 300w, https:\/\/neuropediatoolkit.org\/wp-content\/uploads\/2022\/11\/imagen-36-768x666.png 768w, https:\/\/neuropediatoolkit.org\/wp-content\/uploads\/2022\/11\/imagen-36-14x12.png 14w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n<div id=\"zotpress-fb0236959346307f607cce3c0255b1d1\" class=\"zp-Zotpress zp-Zotpress-Bib wp-block-group\">\n\n\t\t<span class=\"ZP_API_USER_ID ZP_ATTR\">332710<\/span>\n\t\t<span class=\"ZP_ITEM_KEY ZP_ATTR\">{332710:HEIEWD9Q}<\/span>\n\t\t<span class=\"ZP_COLLECTION_ID ZP_ATTR\"><\/span>\n\t\t<span class=\"ZP_TAG_ID ZP_ATTR\"><\/span>\n\t\t<span class=\"ZP_AUTHOR ZP_ATTR\"><\/span>\n\t\t<span class=\"ZP_YEAR ZP_ATTR\"><\/span>\n        <span class=\"ZP_ITEMTYPE ZP_ATTR\"><\/span>\n\t\t<span class=\"ZP_INCLUSIVE ZP_ATTR\">1<\/span>\n\t\t<span class=\"ZP_STYLE ZP_ATTR\">vancouver<\/span>\n\t\t<span class=\"ZP_LIMIT ZP_ATTR\">50<\/span>\n\t\t<span class=\"ZP_SORTBY ZP_ATTR\">default<\/span>\n\t\t<span class=\"ZP_ORDER 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id=\"zp-ID-3561-332710-HEIEWD9Q\" data-zp-author-date='Daguenet-et-al.-2015-12' data-zp-date-author='2015-12-Daguenet-et-al.' data-zp-date='2015-12' data-zp-year='2015' data-zp-itemtype='journalArticle' class=\"zp-Entry zpSearchResultsItem\">\n<div class=\"csl-bib-body\" style=\"line-height: 1.35; \">\n  <div class=\"csl-entry\" style=\"clear: left; \">\n    <div class=\"csl-left-margin\" style=\"float: left; padding-right: 0.5em; text-align: right; width: 1em;\">1.<\/div><div class=\"csl-right-inline\" style=\"margin: 0 .4em 0 1.5em;\">Daguenet E, Dujardin G, Valc\u00e1rcel J. The pathogenicity of splicing defects: mechanistic insights into pre-mRNA processing inform novel therapeutic approaches. EMBO reports [Internet]. 2015 Dec [cited 2022 Nov 3];16(12):1640\u201355. Available from: <a class='zp-ItemURL' href='https:\/\/www.embopress.org\/doi\/full\/10.15252\/embr.201541116'>https:\/\/www.embopress.org\/doi\/full\/10.15252\/embr.201541116<\/a><\/div>\n  <\/div>\n<\/div>\n\t\t\t\t<\/div><!-- .zp-Entry .zpSearchResultsItem -->\n\t\t\t<\/div><!-- .zp-zp-SEO-Content -->\n\t\t<\/div><!-- .zp-List -->\n\t<\/div><!--.zp-Zotpress-->\n\n\n","protected":false},"excerpt":{"rendered":"<p>Los oligonucle\u00f3tidos antisentido son la primera terapia g\u00e9nica (en realidad terapia RNA antisentido, ya que no modifican el c\u00f3digo gen\u00e9tico) disponible en el mercado para el tratamiento de enfermedades neurogen\u00e9ticas. Se basan en la t\u00e9cnica del salto del ex\u00f3n (Duchenne) o de la inclusi\u00f3n del ex\u00f3n (AME). Pr\u00f3ximamente estar\u00e1 disponible tambi\u00e9n tratamiento para la distrofia &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/neuropediatoolkit.org\/en\/oligonucleotidos-antisentido\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> \u00abOligonucle\u00f3tidos antisentido.\u00bb<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":3564,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[10],"tags":[],"class_list":["post-3561","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-neurogenetica","entry"],"_links":{"self":[{"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/posts\/3561","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/comments?post=3561"}],"version-history":[{"count":0,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/posts\/3561\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/media\/3564"}],"wp:attachment":[{"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/media?parent=3561"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/categories?post=3561"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/tags?post=3561"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}