{"id":3693,"date":"2022-11-05T18:28:10","date_gmt":"2022-11-05T18:28:10","guid":{"rendered":"https:\/\/neuropediatoolbox.org\/?p=3693"},"modified":"2022-11-05T18:33:36","modified_gmt":"2022-11-05T18:33:36","slug":"sinaptopatias","status":"publish","type":"post","link":"https:\/\/neuropediatoolkit.org\/en\/sinaptopatias\/","title":{"rendered":"Sinaptopat\u00edas."},"content":{"rendered":"<p>Sentinel events. <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><em><a href=\"\/en\/Intellectual disability.\/\">Neonatal hypoxic-ischemic encephalopathy (HIE) is a clinical syndrome of acute neurological dysfunction occurring in term or late preterm newborns secondary to a perinatal asphyxia event, and is one of the leading causes of mortality and long-term neurological sequelae (cerebral palsy, developmental delay, epilepsy, etc.).<\/a><\/em>Diagnosis is based on a combination of clinical criteria (need for resuscitation, low Apgar, altered state of alertness), laboratory parameters (severe acidemia in umbilical cord or neonatal blood gas analysis), and monitoring (abnormal aEEG). <\/li>\n\n\n\n<li><em><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK475803\/\">Therapeutic hypothermia initiated within the first 6 hours of life is the only effective treatment to reduce death and disability in newborns with moderate or severe HIE.<\/a><\/em>{332710:GSPGSS3E};{332710:HSPJSS3A} <\/li>\n\n\n\n<li><em><a href=\"\/en\/Comorbid diagnosis.\/\">Sarnat HB, Sarnat MS. Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study. Archives of Neurology. 1976 Oct 1;33(10):696&#x2013;705.<\/a><\/em>{332710:GSPGSS3E};{332710:HSPJSS3A} <\/li>\n\n\n\n<li><em><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1198\/\">Embedded from Neonatal hypoxic-ischemic encephalopathy.<\/a><\/em>Autism spectrum disorder. <\/li>\n<\/ul>\n\n\n\n<p>There is a Spanish research group dedicated to <a href=\"\/en\/Neurodevelopmental disorders.\/\">Criterion E.<\/a>. <\/p>\n\n\n\n<p><\/p>","protected":false},"excerpt":{"rendered":"<p>The comorbid diagnosis of ASD and ID requires that social communication be below what is expected for the general developmental level (Criterion E of DSM-5). The clinical differentiation between both entities in young children or those with severe disability is particularly complex, requiring a multidisciplinary approach and systematic phenotypic refinement.<\/p>","protected":false},"author":1,"featured_media":3695,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[3,10,43],"tags":[],"class_list":["post-3693","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-enfermedades-neurologicas","category-neurogenetica","category-trastornos-del-neurodesarrollo","entry"],"_links":{"self":[{"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/posts\/3693","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/comments?post=3693"}],"version-history":[{"count":0,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/posts\/3693\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/media\/3695"}],"wp:attachment":[{"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/media?parent=3693"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/categories?post=3693"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/tags?post=3693"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}