{"id":4520,"date":"2023-02-19T18:08:37","date_gmt":"2023-02-19T18:08:37","guid":{"rendered":"https:\/\/neuropediatoolbox.org\/?p=4520"},"modified":"2026-06-22T16:28:59","modified_gmt":"2026-06-22T16:28:59","slug":"trayectorias-de-desarrollo-de-las-cln","status":"publish","type":"post","link":"https:\/\/neuropediatoolkit.org\/en\/trayectorias-de-desarrollo-de-las-cln\/","title":{"rendered":"CLN development trajectories."},"content":{"rendered":"<h2 class=\"wp-block-heading\">Ceroidal Neuronal Lipofuscinosis (CLN): Developmental Trajectories<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Neuronal ceroid lipofuscinosis (CLN), commonly called Batten disease, group together a group of rare lysosomal-based neurodegenerative disorders characterized by the intralysosomal accumulation of fluorescent ceroid lipofuscin material.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Common Path of Symptoms<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n    <li>Progressive and rapid loss of visual acuity leading to blindness (often the first sign).<\/li>\n    <li>Myoclonic and focal epileptic seizures refractory to pharmacological treatment.<\/li>\n    <li>Progressive regression of cognitive (dementia) and motor milestones.<\/li>\n    <li>Generalized motor impairment with profound spasticity and premature death.<\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Neuronal Ceroid Lipofuscinosis (CLN): Developmental Trajectories Ceroid neuronal lipofuscinosis (CLN), commonly called Batten disease, group together a set of rare lysosomal-based neurodegenerative disorders characterized by the intralysosomal accumulation of fluorescent ceroid lipofuscin material. Common Path of Symptoms Progressive and rapid loss of visual acuity leading to blindness (to... <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/neuropediatoolkit.org\/en\/trayectorias-de-desarrollo-de-las-cln\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> \u00abDevelopment trajectories of CLNs.\u00bb<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":4535,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[49],"tags":[],"class_list":["post-4520","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-neurodegenerativas","entry"],"_links":{"self":[{"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/posts\/4520","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/comments?post=4520"}],"version-history":[{"count":2,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/posts\/4520\/revisions"}],"predecessor-version":[{"id":8293,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/posts\/4520\/revisions\/8293"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/media\/4535"}],"wp:attachment":[{"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/media?parent=4520"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/categories?post=4520"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/tags?post=4520"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}