{"id":4523,"date":"2023-02-19T18:10:27","date_gmt":"2023-02-19T18:10:27","guid":{"rendered":"https:\/\/neuropediatoolbox.org\/?p=4523"},"modified":"2026-06-22T16:28:58","modified_gmt":"2026-06-22T16:28:58","slug":"trayectoria-de-desarrollo-de-la-mld-leucodistrofia-metacromatica","status":"publish","type":"post","link":"https:\/\/neuropediatoolkit.org\/en\/trayectoria-de-desarrollo-de-la-mld-leucodistrofia-metacromatica\/","title":{"rendered":"Developmental trajectory of MLD (metachromatic leukodystrophy)."},"content":{"rendered":"<h2 class=\"wp-block-heading\">Metachromatic Leukodystrophy (MLD): Developmental Trajectories<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Metachromatic leukodystrophy is an autosomal recessive inherited lysosomal storage disease characterized by deficiency of the enzyme arylsulfatase A (ARSA), causing the accumulation of sulfatides and progressive demyelination of the central and peripheral nervous system.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Clinical Forms and Trajectory<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n    <li><strong>Late Infant (typical):<\/strong> It appears between the first and second year of life. Infants lose acquired walking ability, present severe motor regression, progressive spastic quadriparesis, and blindness.<\/li>\n    <li><strong>Youth and Adult:<\/strong> Slower progression, initially characterized by learning difficulties, behavioral disorders, ataxia and subsequent global motor impairment.<\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Metachromatic Leukodystrophy (MLD): Developmental Trajectories Metachromatic leukodystrophy is an autosomal recessive inherited lysosomal storage disease characterized by deficiency of the enzyme arylsulfatase A (ARSA), causing the accumulation of sulfatides and progressive demyelination of the central and peripheral nervous system. Clinical Forms and Late Childhood Trajectory (typical): It manifests between the first\u2026 <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/neuropediatoolkit.org\/en\/trayectoria-de-desarrollo-de-la-mld-leucodistrofia-metacromatica\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> \"Developmental trajectory of MLD (metachromatic leukodystrophy).\"<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":4525,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[49],"tags":[],"class_list":["post-4523","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-neurodegenerativas","entry"],"_links":{"self":[{"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/posts\/4523","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/comments?post=4523"}],"version-history":[{"count":2,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/posts\/4523\/revisions"}],"predecessor-version":[{"id":8292,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/posts\/4523\/revisions\/8292"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/media\/4525"}],"wp:attachment":[{"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/media?parent=4523"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/categories?post=4523"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/tags?post=4523"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}