{"id":4523,"date":"2023-02-19T18:10:27","date_gmt":"2023-02-19T18:10:27","guid":{"rendered":"https:\/\/neuropediatoolbox.org\/?p=4523"},"modified":"2026-06-22T16:28:58","modified_gmt":"2026-06-22T16:28:58","slug":"trayectoria-de-desarrollo-de-la-mld-leucodistrofia-metacromatica","status":"publish","type":"post","link":"https:\/\/neuropediatoolkit.org\/en\/trayectoria-de-desarrollo-de-la-mld-leucodistrofia-metacromatica\/","title":{"rendered":"Developmental trajectory of MLD (metachromatic leukodystrophy)."},"content":{"rendered":"<h2 class=\"wp-block-heading\">Leucodistrofia Metacrom\u00e1tica (MLD): Trayectorias de Desarrollo<\/h2>\n\n\n\n<p>La leucodistrofia metacrom\u00e1tica es una enfermedad de dep\u00f3sito lisosomal hereditaria autos\u00f3mica recesiva caracterizada por la deficiencia de la enzima arilsulfatasa A (ARSA), causando la acumulaci\u00f3n de sulf\u00e1tidos y la desmielinizaci\u00f3n progresiva del sistema nervioso central y perif\u00e9rico.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Formas Cl\u00ednicas y Trayectoria<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n    <li><strong>Infantil Tard\u00eda (t\u00edpica):<\/strong> Se manifiesta entre el primer y segundo a\u00f1o de vida. Los lactantes pierden la capacidad de marcha adquirida, presentan regresi\u00f3n motora grave, cuadriparesia esp\u00e1stica progresiva y ceguera.<\/li>\n    <li><strong>Juvenil y Adulta:<\/strong> De progresi\u00f3n m\u00e1s lenta, caracterizadas inicialmente por dificultades de aprendizaje, trastornos de conducta, ataxia y posterior afectaci\u00f3n motora global.<\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Metachromatic Leukodystrophy (MLD): Developmental Trajectories Metachromatic leukodystrophy is an autosomal recessive inherited lysosomal storage disease characterized by deficiency of the enzyme arylsulfatase A (ARSA), causing the accumulation of sulfatides and progressive demyelination of the central and peripheral nervous system. Clinical Forms and Late Childhood Trajectory (typical): It manifests between the first\u2026 <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/neuropediatoolkit.org\/en\/trayectoria-de-desarrollo-de-la-mld-leucodistrofia-metacromatica\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> \u00abTrayectoria de desarrollo de la MLD (leucodistrofia metacrom\u00e1tica).\u00bb<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":4525,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[49],"tags":[],"class_list":["post-4523","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-neurodegenerativas","entry"],"_links":{"self":[{"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/posts\/4523","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/comments?post=4523"}],"version-history":[{"count":2,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/posts\/4523\/revisions"}],"predecessor-version":[{"id":8292,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/posts\/4523\/revisions\/8292"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/media\/4525"}],"wp:attachment":[{"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/media?parent=4523"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/categories?post=4523"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/tags?post=4523"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}