![\"Epilepsy-related](\"https:\/\/neuropediatoolkit.org\/wp-content\/uploads\/2024\/07\/Epilepsy-related-genetic-conditions-displaying-potential-specific-therapeutic-approaches.png\")
Desglose Cl\u00ednico de los Abordajes Terap\u00e9uticos Representados<\/h3>\n\n
A continuaci\u00f3n se detallan las principales categor\u00edas moleculares y las dianas terap\u00e9uticas representadas en la tabla:<\/p>\n\n
1. Canalopat\u00edas de Sodio y Potasio<\/h4>\n\n - SCN1A (S\u00edndrome de Dravet – P\u00e9rdida de funci\u00f3n):<\/strong> Abordaje de precisi\u00f3n con fenfluramina, cannabidiol, estiripentol, clobazam y valproato<\/em>. Alerta de precisi\u00f3n:<\/strong> Est\u00e1n formalmente contraindicados los bloqueadores de canales de sodio (carbamazepina, fenito\u00edna, lamotrigina) por riesgo de empeoramiento severo y crisis refractarias.<\/li>\n
- SCN2A y SCN8A (Variantes de Ganancia de Funci\u00f3n en debut temprano):<\/strong> Indicaci\u00f3n preferente de bloqueadores de canales de sodio<\/em> a dosis altas (fenito\u00edna, carbamazepina), que restablecen la hiperexcitabilidad de membrana.<\/li>\n
- KCNQ2 \/ KCNQ3 (Canales de potasio Kv7.2\/Kv7.3):<\/strong> Apertura selectiva de canales K+ mediante retigabina (ezogabina)<\/em> y respuesta favorable a bloqueadores de sodio como carbamazepina en fases tempranas.<\/li>\n
- KCNT1 (Canales de potasio dependientes de Na+):<\/strong> Uso de quinidina<\/em> como modulador espec\u00edfico off-label en epilepsias focales migrantes infantiles refractarias.<\/li>\n<\/ul>\n\n
2. Trastornos Metab\u00f3licos y del Transporte Cerebral<\/h4>\n\n - SLC2A1 (D\u00e9ficit del transportador cerebral de glucosa GLUT1):<\/strong> Terapia de sustituci\u00f3n obligada mediante Dieta Cetog\u00e9nica<\/em> precoz, aportando cuerpos cet\u00f3nicos como sustrato energ\u00e9tico cerebral alternativo a la glucosa.<\/li>\n
- ALDH7A1 \/ PNPO (Epilepsias dependientes de piridoxina):<\/strong> Suplementaci\u00f3n espec\u00edfica de por vida con piridoxina (vitamina B6)<\/em> o piridoxal 5′-fosfato (PLP)<\/em>.<\/li>\n<\/ul>\n\n
3. mTORopat\u00edas y V\u00edas de Proliferaci\u00f3n\/Se\u00f1alizaci\u00f3n<\/h4>\n\n - TSC1 \/ TSC2 (Complejo de Esclerosis Tuberosa) y DEPDC5 \/ NPRL2 \/ NPRL3 (Complejo GATOR1):<\/strong> Hiperactivaci\u00f3n de la cascada intracelular mTOR. Abordaje dirigido con inhibidores de mTOR (Everolimus, Sirolimus)<\/em> para el control de crisis y displasias corticales focales asociadas.<\/li>\n<\/ul>\n\n
4. Moduladores de Receptores y V\u00edas Sin\u00e1pticas<\/h4>\n\n - GRIN2A \/ GRIN2B (Subunidades de receptores NMDA):<\/strong> Modulaci\u00f3n alost\u00e9rica y bloqueo de receptores NMDA mediante memantina<\/em> en variantes con ganancia de funci\u00f3n.<\/li>\n
- PCDH19 (Protocadherina 19):<\/strong> Terapias moduladoras de neuroesteroides (ganaxolona<\/em>) y protocolos hormonales espec\u00edficos.<\/li>\n<\/ul>\n\n
Bibliograf\u00eda<\/h3>\n\n\n\t\t19955111<\/span>\n\t\t{19955111:6YYVTK6C}<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n <\/span>\n\t\t1<\/span>\n\t\tvancouver<\/span>\n\t\t50<\/span>\n\t\tdefault<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n <\/span>\n 7473<\/span>\n\t\thttps:\/\/neuropediatoolkit.org\/wp-content\/plugins\/zotpress\/<\/span>\n\n\t\t\n\t\t\t\n\t\t\t\t<\/span>%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%226YYVTK6C%22%2C%22library%22%3A%7B%22id%22%3A19955111%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Beltr%5Cu00e1n-Corbellini%20et%20al.%22%2C%22parsedDate%22%3A%222022-02-17%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%20%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BBeltr%26%23xE1%3Bn-Corbellini%20%26%23xC1%3B%2C%20Aledo-Serrano%20%26%23xC1%3B%2C%20M%26%23xF8%3Bller%20RS%2C%20P%26%23xE9%3Brez-Palma%20E%2C%20Garc%26%23xED%3Ba-Morales%20I%2C%20Toledano%20R%2C%20et%20al.%20Epilepsy%20Genetics%20and%20Precision%20Medicine%20in%20Adults%3A%20A%20New%20Landscape%20for%20Developmental%20and%20Epileptic%20Encephalopathies.%20Front%20Neurol%20%5BInternet%5D.%202022%20Feb%2017%20%5Bcited%202026%20June%2015%5D%3B13.%20Available%20from%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Fjournals%5C%2Fneurology%5C%2Farticles%5C%2F10.3389%5C%2Ffneur.2022.777115%5C%2Ffull%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Fjournals%5C%2Fneurology%5C%2Farticles%5C%2F10.3389%5C%2Ffneur.2022.777115%5C%2Ffull%26lt%3B%5C%2Fa%26gt%3B%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Epilepsy%20Genetics%20and%20Precision%20Medicine%20in%20Adults%3A%20A%20New%20Landscape%20for%20Developmental%20and%20Epileptic%20Encephalopathies%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22%5Cu00c1lvaro%22%2C%22lastName%22%3A%22Beltr%5Cu00e1n-Corbellini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22%5Cu00c1ngel%22%2C%22lastName%22%3A%22Aledo-Serrano%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rikke%20S.%22%2C%22lastName%22%3A%22M%5Cu00f8ller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eduardo%22%2C%22lastName%22%3A%22P%5Cu00e9rez-Palma%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Irene%22%2C%22lastName%22%3A%22Garc%5Cu00eda-Morales%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Toledano%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antonio%22%2C%22lastName%22%3A%22Gil-Nagel%22%7D%5D%2C%22abstractNote%22%3A%22This%20review%20aims%20to%20provide%20an%20updated%20perspective%20of%20epilepsy%20genetics%20and%20precision%20medicine%20in%20adult%20patients%2C%20with%20special%20focus%20on%20developmental%20and%20epileptic%20encephalopathies%20%28DEEs%29%2C%20covering%20relevant%20and%20controversial%20issues%2C%20such%20as%20defining%20candidates%20for%20genetic%20testing%2C%20which%20genetic%20tests%20to%20request%20and%20how%20to%20interpret%20them.%20A%20literature%20review%20was%20conducted%2C%20including%20findings%20in%20the%20discussion%20and%20recommendations.%20DEEs%20are%20wide%20and%20phenotypically%20heterogeneous%20electroclinical%20syndromes.%20They%20generally%20have%20a%20pediatric%20presentation%2C%20but%20patients%20frequently%20reach%20adulthood%20still%20undiagnosed.%20Identifying%20the%20etiology%20is%20essential%2C%20because%20there%20lies%20the%20key%20for%20precision%20medicine.%20Phenotypes%20modify%20according%20to%20age%2C%20and%20although%20deep%20phenotyping%20has%20allowed%20to%20outline%20certain%20entities%2C%20genotype-phenotype%20correlations%20are%20still%20poor%2C%20commonly%20leading%20to%20long-lasting%20diagnostic%20odysseys%20and%20ineffective%20therapies.%20Recent%20adult%20series%20show%20that%20the%20target%20patients%20to%20be%20identified%20for%20genetic%20testing%20are%20those%20with%20epilepsy%20and%20different%20risk%20factors.%20The%20clinician%20should%20take%20active%20part%20in%20the%20assessment%20of%20the%20pathogenicity%20of%20the%20variants%20detected%2C%20especially%20concerning%20variants%20of%20uncertain%20significance.%20An%20accurate%20diagnosis%20implies%20precision%20medicine%2C%20meaning%20genetic%20counselling%2C%20prognosis%2C%20possible%20future%20therapies%2C%20and%20a%20reduction%20of%20iatrogeny.%20Up%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\n 1.<\/div>Beltr\u00e1n-Corbellini \u00c1, Aledo-Serrano \u00c1, M\u00f8ller RS, P\u00e9rez-Palma E, Garc\u00eda-Morales I, Toledano R, et al. Epilepsy Genetics and Precision Medicine in Adults: A New Landscape for Developmental and Epileptic Encephalopathies. Front Neurol [Internet]. 2022 Feb 17 [cited 2026 June 15];13. Available from: https:\/\/www.frontiersin.org\/journals\/neurology\/articles\/10.3389\/fneur.2022.777115\/full<\/a><\/div>\n <\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n\n\n","protected":false},"excerpt":{"rendered":"Precision Medicine in Genetic Epilepsy and Developmental Encephalopathies (DEEs) Precision medicine in neurodevelopmental and epileptic encephalopathies (DEEs) seeks to direct pharmacological treatment towards the pathophysiological and molecular mechanism underlying the patient's genetic variant, avoiding ineffective or harmful therapies. Clinical Breakdown of Therapeutic Approaches Represented Below\u2026 <\/p>\n
2. Trastornos Metab\u00f3licos y del Transporte Cerebral<\/h4>\n\n - SLC2A1 (D\u00e9ficit del transportador cerebral de glucosa GLUT1):<\/strong> Terapia de sustituci\u00f3n obligada mediante Dieta Cetog\u00e9nica<\/em> precoz, aportando cuerpos cet\u00f3nicos como sustrato energ\u00e9tico cerebral alternativo a la glucosa.<\/li>\n
- ALDH7A1 \/ PNPO (Epilepsias dependientes de piridoxina):<\/strong> Suplementaci\u00f3n espec\u00edfica de por vida con piridoxina (vitamina B6)<\/em> o piridoxal 5′-fosfato (PLP)<\/em>.<\/li>\n<\/ul>\n\n
3. mTORopat\u00edas y V\u00edas de Proliferaci\u00f3n\/Se\u00f1alizaci\u00f3n<\/h4>\n\n - TSC1 \/ TSC2 (Complejo de Esclerosis Tuberosa) y DEPDC5 \/ NPRL2 \/ NPRL3 (Complejo GATOR1):<\/strong> Hiperactivaci\u00f3n de la cascada intracelular mTOR. Abordaje dirigido con inhibidores de mTOR (Everolimus, Sirolimus)<\/em> para el control de crisis y displasias corticales focales asociadas.<\/li>\n<\/ul>\n\n
4. Moduladores de Receptores y V\u00edas Sin\u00e1pticas<\/h4>\n\n - GRIN2A \/ GRIN2B (Subunidades de receptores NMDA):<\/strong> Modulaci\u00f3n alost\u00e9rica y bloqueo de receptores NMDA mediante memantina<\/em> en variantes con ganancia de funci\u00f3n.<\/li>\n
- PCDH19 (Protocadherina 19):<\/strong> Terapias moduladoras de neuroesteroides (ganaxolona<\/em>) y protocolos hormonales espec\u00edficos.<\/li>\n<\/ul>\n\n
Bibliograf\u00eda<\/h3>\n\n\n\t\t19955111<\/span>\n\t\t{19955111:6YYVTK6C}<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n <\/span>\n\t\t1<\/span>\n\t\tvancouver<\/span>\n\t\t50<\/span>\n\t\tdefault<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n <\/span>\n 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\n 1.<\/div>Beltr\u00e1n-Corbellini \u00c1, Aledo-Serrano \u00c1, M\u00f8ller RS, P\u00e9rez-Palma E, Garc\u00eda-Morales I, Toledano R, et al. Epilepsy Genetics and Precision Medicine in Adults: A New Landscape for Developmental and Epileptic Encephalopathies. Front Neurol [Internet]. 2022 Feb 17 [cited 2026 June 15];13. Available from: https:\/\/www.frontiersin.org\/journals\/neurology\/articles\/10.3389\/fneur.2022.777115\/full<\/a><\/div>\n <\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n\n\n","protected":false},"excerpt":{"rendered":"Precision Medicine in Genetic Epilepsy and Developmental Encephalopathies (DEEs) Precision medicine in neurodevelopmental and epileptic encephalopathies (DEEs) seeks to direct pharmacological treatment towards the pathophysiological and molecular mechanism underlying the patient's genetic variant, avoiding ineffective or harmful therapies. Clinical Breakdown of Therapeutic Approaches Represented Below\u2026 <\/p>\n
3. mTORopat\u00edas y V\u00edas de Proliferaci\u00f3n\/Se\u00f1alizaci\u00f3n<\/h4>\n\n - TSC1 \/ TSC2 (Complejo de Esclerosis Tuberosa) y DEPDC5 \/ NPRL2 \/ NPRL3 (Complejo GATOR1):<\/strong> Hiperactivaci\u00f3n de la cascada intracelular mTOR. Abordaje dirigido con inhibidores de mTOR (Everolimus, Sirolimus)<\/em> para el control de crisis y displasias corticales focales asociadas.<\/li>\n<\/ul>\n\n
4. Moduladores de Receptores y V\u00edas Sin\u00e1pticas<\/h4>\n\n - GRIN2A \/ GRIN2B (Subunidades de receptores NMDA):<\/strong> Modulaci\u00f3n alost\u00e9rica y bloqueo de receptores NMDA mediante memantina<\/em> en variantes con ganancia de funci\u00f3n.<\/li>\n
- PCDH19 (Protocadherina 19):<\/strong> Terapias moduladoras de neuroesteroides (ganaxolona<\/em>) y protocolos hormonales espec\u00edficos.<\/li>\n<\/ul>\n\n
Bibliograf\u00eda<\/h3>\n\n\n\t\t19955111<\/span>\n\t\t{19955111:6YYVTK6C}<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n <\/span>\n\t\t1<\/span>\n\t\tvancouver<\/span>\n\t\t50<\/span>\n\t\tdefault<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n <\/span>\n 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\n 1.<\/div>Beltr\u00e1n-Corbellini \u00c1, Aledo-Serrano \u00c1, M\u00f8ller RS, P\u00e9rez-Palma E, Garc\u00eda-Morales I, Toledano R, et al. Epilepsy Genetics and Precision Medicine in Adults: A New Landscape for Developmental and Epileptic Encephalopathies. Front Neurol [Internet]. 2022 Feb 17 [cited 2026 June 15];13. Available from: https:\/\/www.frontiersin.org\/journals\/neurology\/articles\/10.3389\/fneur.2022.777115\/full<\/a><\/div>\n <\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n\n\n","protected":false},"excerpt":{"rendered":"Precision Medicine in Genetic Epilepsy and Developmental Encephalopathies (DEEs) Precision medicine in neurodevelopmental and epileptic encephalopathies (DEEs) seeks to direct pharmacological treatment towards the pathophysiological and molecular mechanism underlying the patient's genetic variant, avoiding ineffective or harmful therapies. Clinical Breakdown of Therapeutic Approaches Represented Below\u2026 <\/p>\n
4. Moduladores de Receptores y V\u00edas Sin\u00e1pticas<\/h4>\n\n - GRIN2A \/ GRIN2B (Subunidades de receptores NMDA):<\/strong> Modulaci\u00f3n alost\u00e9rica y bloqueo de receptores NMDA mediante memantina<\/em> en variantes con ganancia de funci\u00f3n.<\/li>\n
- PCDH19 (Protocadherina 19):<\/strong> Terapias moduladoras de neuroesteroides (ganaxolona<\/em>) y protocolos hormonales espec\u00edficos.<\/li>\n<\/ul>\n\n
Bibliograf\u00eda<\/h3>\n\n\n\t\t19955111<\/span>\n\t\t{19955111:6YYVTK6C}<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n <\/span>\n\t\t1<\/span>\n\t\tvancouver<\/span>\n\t\t50<\/span>\n\t\tdefault<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n <\/span>\n 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\n 1.<\/div>Beltr\u00e1n-Corbellini \u00c1, Aledo-Serrano \u00c1, M\u00f8ller RS, P\u00e9rez-Palma E, Garc\u00eda-Morales I, Toledano R, et al. Epilepsy Genetics and Precision Medicine in Adults: A New Landscape for Developmental and Epileptic Encephalopathies. Front Neurol [Internet]. 2022 Feb 17 [cited 2026 June 15];13. Available from: https:\/\/www.frontiersin.org\/journals\/neurology\/articles\/10.3389\/fneur.2022.777115\/full<\/a><\/div>\n <\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n\n\n","protected":false},"excerpt":{"rendered":"Precision Medicine in Genetic Epilepsy and Developmental Encephalopathies (DEEs) Precision medicine in neurodevelopmental and epileptic encephalopathies (DEEs) seeks to direct pharmacological treatment towards the pathophysiological and molecular mechanism underlying the patient's genetic variant, avoiding ineffective or harmful therapies. Clinical Breakdown of Therapeutic Approaches Represented Below\u2026 <\/p>\n
Bibliograf\u00eda<\/h3>\n\n\n\t\t19955111<\/span>\n\t\t{19955111:6YYVTK6C}<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n <\/span>\n\t\t1<\/span>\n\t\tvancouver<\/span>\n\t\t50<\/span>\n\t\tdefault<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n <\/span>\n 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\n 1.<\/div>Beltr\u00e1n-Corbellini \u00c1, Aledo-Serrano \u00c1, M\u00f8ller RS, P\u00e9rez-Palma E, Garc\u00eda-Morales I, Toledano R, et al. Epilepsy Genetics and Precision Medicine in Adults: A New Landscape for Developmental and Epileptic Encephalopathies. Front Neurol [Internet]. 2022 Feb 17 [cited 2026 June 15];13. Available from: https:\/\/www.frontiersin.org\/journals\/neurology\/articles\/10.3389\/fneur.2022.777115\/full<\/a><\/div>\n <\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n\n\n","protected":false},"excerpt":{"rendered":"Precision Medicine in Genetic Epilepsy and Developmental Encephalopathies (DEEs) Precision medicine in neurodevelopmental and epileptic encephalopathies (DEEs) seeks to direct pharmacological treatment towards the pathophysiological and molecular mechanism underlying the patient's genetic variant, avoiding ineffective or harmful therapies. Clinical Breakdown of Therapeutic Approaches Represented Below\u2026 <\/p>\n
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Beltr\u00e1n-Corbellini \u00c1, Aledo-Serrano \u00c1, M\u00f8ller RS, P\u00e9rez-Palma E, Garc\u00eda-Morales I, Toledano R, et al. Epilepsy Genetics and Precision Medicine in Adults: A New Landscape for Developmental and Epileptic Encephalopathies. Front Neurol [Internet]. 2022 Feb 17 [cited 2026 June 15];13. Available from: https:\/\/www.frontiersin.org\/journals\/neurology\/articles\/10.3389\/fneur.2022.777115\/full<\/a><\/div>\n <\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n\n\n","protected":false},"excerpt":{"rendered":"
Precision Medicine in Genetic Epilepsy and Developmental Encephalopathies (DEEs) Precision medicine in neurodevelopmental and epileptic encephalopathies (DEEs) seeks to direct pharmacological treatment towards the pathophysiological and molecular mechanism underlying the patient's genetic variant, avoiding ineffective or harmful therapies. Clinical Breakdown of Therapeutic Approaches Represented Below\u2026 <\/p>\n