{"id":7913,"date":"2025-07-20T19:07:25","date_gmt":"2025-07-20T19:07:25","guid":{"rendered":"https:\/\/neuropediatoolkit.org\/?p=7913"},"modified":"2026-06-22T16:28:48","modified_gmt":"2026-06-22T16:28:48","slug":"cdl-facial-phenotypes","status":"publish","type":"post","link":"https:\/\/neuropediatoolkit.org\/en\/cdl-facial-phenotypes\/","title":{"rendered":"CdL facial phenotypes."},"content":{"rendered":"<h2 class=\"wp-block-heading\">Facial Phenotypes in Cornelia de Lange Syndrome (CdLS)<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Cornelia de Lange syndrome (CdLS) is associated with a characteristic facial dysmorphic pattern that facilitates its clinical diagnosis:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n    <li><strong>Synophridia:<\/strong> Very well defined eyebrows, arched and united in the midline, along with unusually long eyelashes.<\/li>\n    <li><strong>Nasal abnormalities:<\/strong> Short nose with depressed nasal bridge, anteverted nostrils (pointing upwards) and bulbous nasal tip.<\/li>\n    <li><strong>Long and flat philtrum:<\/strong> Increased distance between the nose and the upper lip, which lacks the usual groove.<\/li>\n    <li><strong>Lips and mouth:<\/strong> Very thin upper lip with the corners of the mouth directed downwards (sad mouth appearance).<\/li>\n    <li><strong>Micrognathia:<\/strong> Small jaw, often accentuated by low set ears.<\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Facial Phenotypes in Cornelia de Lange Syndrome (CdLS) Cornelia de Lange syndrome (CdLS) is associated with a characteristic facial dysmorphic pattern that facilitates its clinical diagnosis: Synophridia: Very well-defined eyebrows, arched and united in the midline, along with unusually long eyelashes. Nasal anomalies: Short nose with depressed nasal bridge,\u2026 <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/neuropediatoolkit.org\/en\/cdl-facial-phenotypes\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> \u00abCdL facial phenotypes.\u00bb<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":7914,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[65,25,10,43],"tags":[],"class_list":["post-7913","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-enfermedades-raras","category-fenotipado","category-neurogenetica","category-trastornos-del-neurodesarrollo","entry"],"_links":{"self":[{"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/posts\/7913","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/comments?post=7913"}],"version-history":[{"count":2,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/posts\/7913\/revisions"}],"predecessor-version":[{"id":8274,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/posts\/7913\/revisions\/8274"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/media\/7914"}],"wp:attachment":[{"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/media?parent=7913"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/categories?post=7913"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/tags?post=7913"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}