{"id":8025,"date":"2025-12-25T19:41:21","date_gmt":"2025-12-25T19:41:21","guid":{"rendered":"https:\/\/neuropediatoolkit.org\/?p=8025"},"modified":"2026-06-16T07:46:24","modified_gmt":"2026-06-16T07:46:24","slug":"paralisis-cerebral-infantil-y-rm-normal","status":"publish","type":"post","link":"https:\/\/neuropediatoolkit.org\/en\/paralisis-cerebral-infantil-y-rm-normal\/","title":{"rendered":"Infantile cerebral palsy and MRI. When to request genetic studies."},"content":{"rendered":"<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img fetchpriority=\"high\" decoding=\"async\" width=\"728\" height=\"668\" src=\"https:\/\/neuropediatoolkit.org\/wp-content\/uploads\/2025\/12\/image-1.png\" alt=\"\" class=\"wp-image-8117\" srcset=\"https:\/\/neuropediatoolkit.org\/wp-content\/uploads\/2025\/12\/image-1.png 728w, https:\/\/neuropediatoolkit.org\/wp-content\/uploads\/2025\/12\/image-1-300x275.png 300w, https:\/\/neuropediatoolkit.org\/wp-content\/uploads\/2025\/12\/image-1-13x12.png 13w\" sizes=\"(max-width: 728px) 100vw, 728px\" \/><\/figure>\n<\/div>\n\n<div id=\"zotpress-54eed3233d3292e4ed06eb26df14c65f\" class=\"zp-Zotpress zp-Zotpress-Bib wp-block-group\">\n\n\t\t<span class=\"ZP_API_USER_ID ZP_ATTR\">19955111<\/span>\n\t\t<span class=\"ZP_ITEM_KEY ZP_ATTR\">{19955111:NMMWTEGD}<\/span>\n\t\t<span class=\"ZP_COLLECTION_ID ZP_ATTR\"><\/span>\n\t\t<span class=\"ZP_TAG_ID ZP_ATTR\"><\/span>\n\t\t<span class=\"ZP_AUTHOR ZP_ATTR\"><\/span>\n\t\t<span class=\"ZP_YEAR ZP_ATTR\"><\/span>\n        <span class=\"ZP_ITEMTYPE ZP_ATTR\"><\/span>\n\t\t<span class=\"ZP_INCLUSIVE ZP_ATTR\">1<\/span>\n\t\t<span class=\"ZP_STYLE ZP_ATTR\">vancouver<\/span>\n\t\t<span class=\"ZP_LIMIT ZP_ATTR\">50<\/span>\n\t\t<span class=\"ZP_SORTBY ZP_ATTR\">default<\/span>\n\t\t<span class=\"ZP_ORDER ZP_ATTR\"><\/span>\n\t\t<span class=\"ZP_TITLE ZP_ATTR\"><\/span>\n\t\t<span class=\"ZP_SHOWIMAGE ZP_ATTR\"><\/span>\n\t\t<span class=\"ZP_SHOWTAGS ZP_ATTR\"><\/span>\n\t\t<span class=\"ZP_DOWNLOADABLE ZP_ATTR\"><\/span>\n\t\t<span class=\"ZP_NOTES ZP_ATTR\"><\/span>\n\t\t<span class=\"ZP_ABSTRACT ZP_ATTR\"><\/span>\n\t\t<span class=\"ZP_CITEABLE ZP_ATTR\"><\/span>\n\t\t<span class=\"ZP_TARGET ZP_ATTR\"><\/span>\n\t\t<span class=\"ZP_URLWRAP ZP_ATTR\"><\/span>\n\t\t<span class=\"ZP_FORCENUM ZP_ATTR\"><\/span>\n        <span class=\"ZP_HIGHLIGHT ZP_ATTR\"><\/span>\n        <span class=\"ZP_POSTID ZP_ATTR\">8025<\/span>\n\t\t<span class=\"ZOTPRESS_PLUGIN_URL ZP_ATTR\">https:\/\/neuropediatoolkit.org\/wp-content\/plugins\/zotpress\/<\/span>\n\n\t\t<div class=\"zp-List loading\">\n\t\t\t<div class=\"zp-SEO-Content\">\n\t\t\t\t<span class=\"ZP_JSON ZP_ATTR\">%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22NMMWTEGD%22%2C%22library%22%3A%7B%22id%22%3A19955111%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Horber%20et%20al.%22%2C%22parsedDate%22%3A%222021-02-09%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%20%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1.%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BHorber%20V%2C%20Grasshoff%20U%2C%20Sellier%20E%2C%20Arnaud%20C%2C%20Kr%26%23xE4%3Bgeloh-Mann%20I%2C%20Himmelmann%20K.%20The%20Role%20of%20Neuroimaging%20and%20Genetic%20Analysis%20in%20the%20Diagnosis%20of%20Children%20With%20Cerebral%20Palsy.%20Front%20Neurol%20%5BInternet%5D.%202021%20Feb%209%20%5Bcited%202026%20Jan%204%5D%3B11.%20Available%20from%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Fjournals%5C%2Fneurology%5C%2Farticles%5C%2F10.3389%5C%2Ffneur.2020.628075%5C%2Ffull%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Fjournals%5C%2Fneurology%5C%2Farticles%5C%2F10.3389%5C%2Ffneur.2020.628075%5C%2Ffull%26lt%3B%5C%2Fa%26gt%3B%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20Role%20of%20Neuroimaging%20and%20Genetic%20Analysis%20in%20the%20Diagnosis%20of%20Children%20With%20Cerebral%20Palsy%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Veronka%22%2C%22lastName%22%3A%22Horber%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ute%22%2C%22lastName%22%3A%22Grasshoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elodie%22%2C%22lastName%22%3A%22Sellier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Catherine%22%2C%22lastName%22%3A%22Arnaud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ingeborg%22%2C%22lastName%22%3A%22Kr%5Cu00e4geloh-Mann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kate%22%2C%22lastName%22%3A%22Himmelmann%22%7D%5D%2C%22abstractNote%22%3A%22Cerebral%20magnetic%20resonance%20imaging%20%28MRI%29%20is%20considered%20an%20important%20tool%20in%20the%20assessment%20of%20a%20child%20with%20cerebral%20palsy%20%28CP%29%2C%20as%20it%20is%20abnormal%20in%20more%20than%2080%25%20of%20children%20with%20CP%2C%20disclosing%20the%20pathogenic%20pattern%20responsible%20for%20the%20neurological%20condition.%20MRI%2C%20therefore%2C%20is%20recommended%20as%20the%20first%20diagnostic%20step%20after%20medical%20history%20taking%20and%20neurological%20examination.With%20the%20advances%20in%20genetic%20diagnostics%2C%20the%20genetic%20contribution%20to%20CP%20is%20increasingly%20discussed%20and%20the%20question%20arises%20about%20the%20role%20of%20genetic%20testing%20in%20the%20diagnosis%20of%20cerebral%20palsy.%20The%20paper%20gives%20an%20overview%20on%20genetic%20findings%20reported%20in%20CP%2C%20which%20are%20discussed%20with%20respect%20to%20the%20underlying%20brain%20pathology%20according%20to%20neuroimaging%20findings.Surveillance%20of%20Cerebral%20Palsy%20in%20Europe%20%28SCPE%29%20classifies%20neuroimaging%20findings%20in%20CP%20into%20five%20categories%2C%20which%20help%20to%20stratify%20decisions%20concerning%20genetic%20testing.%20Predominant%20white%20and%20grey%20matter%20injuries%20are%20by%20far%20predominant%20%28accounting%20for%20around%2050%25%20and%2020%25%20of%20findings%29.%20They%20are%20considered%20to%20be%20acquired.%20Here%2C%20predisposing%20genetic%20factors%20may%20play%20a%20role%20to%20increase%20vulnerability%20%28and%20should%20especially%20be%20considered%2C%20when%20family%20history%20is%20positive%20and%5C%2For%20causative%20external%20factors%20are%20missing%29.%20In%20maldevelopments%20and%20normal%20findings%20%28around%2011%25%20each%29%2C%20monogenic%20causes%20are%20more%20likely%20and%20thus%2C%20genetic%20testing%20is%20clearly%20recommended.%20In%20the%20miscellaneous%20category%2C%20the%20precise%20nature%20of%20the%20MRI%20finding%20has%20to%20be%20considered%20as%20it%20could%20indicate%20a%20genetic%20origin.%22%2C%22date%22%3A%222021-02-09%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.3389%5C%2Ffneur.2020.628075%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Fjournals%5C%2Fneurology%5C%2Farticles%5C%2F10.3389%5C%2Ffneur.2020.628075%5C%2Ffull%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221664-2295%22%2C%22language%22%3A%22English%22%2C%22collections%22%3A%5B%22D3GNDRTB%22%5D%2C%22dateModified%22%3A%222026-05-09T06%3A25%3A47Z%22%7D%7D%5D%7D<\/span>\n\n\t\t\t\t<div id=\"zp-ID-8025-19955111-NMMWTEGD\" data-zp-author-date='Horber-et-al.-2021-02-09' data-zp-date-author='2021-02-09-Horber-et-al.' data-zp-date='2021-02-09' data-zp-year='2021' data-zp-itemtype='journalArticle' class=\"zp-Entry zpSearchResultsItem\">\n<div class=\"csl-bib-body\" style=\"line-height: 1.35; \">\n  <div class=\"csl-entry\" style=\"clear: left; \">\n    <div class=\"csl-left-margin\" style=\"float: left; padding-right: 0.5em; text-align: right; width: 1em;\">1.<\/div><div class=\"csl-right-inline\" style=\"margin: 0 .4em 0 1.5em;\">Horber V, Grasshoff U, Sellier E, Arnaud C, Kr\u00e4geloh-Mann I, Himmelmann K. The Role of Neuroimaging and Genetic Analysis in the Diagnosis of Children With Cerebral Palsy. Front Neurol [Internet]. 2021 Feb 9 [cited 2026 Jan 4];11. Available from: <a class='zp-ItemURL' href='https:\/\/www.frontiersin.org\/journals\/neurology\/articles\/10.3389\/fneur.2020.628075\/full'>https:\/\/www.frontiersin.org\/journals\/neurology\/articles\/10.3389\/fneur.2020.628075\/full<\/a><\/div>\n  <\/div>\n<\/div>\n\t\t\t\t<\/div><!-- .zp-Entry .zpSearchResultsItem -->\n\t\t\t<\/div><!-- .zp-zp-SEO-Content -->\n\t\t<\/div><!-- .zp-List -->\n\t<\/div><!--.zp-Zotpress-->\n\n\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":8027,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[10,12],"tags":[],"class_list":["post-8025","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-neurogenetica","category-neurorradiologia","entry"],"_links":{"self":[{"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/posts\/8025","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/comments?post=8025"}],"version-history":[{"count":5,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/posts\/8025\/revisions"}],"predecessor-version":[{"id":8122,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/posts\/8025\/revisions\/8122"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/media\/8027"}],"wp:attachment":[{"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/media?parent=8025"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/categories?post=8025"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/en\/wp-json\/wp\/v2\/tags?post=8025"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}