{"id":7990,"date":"2025-12-19T13:22:01","date_gmt":"2025-12-19T13:22:01","guid":{"rendered":"https:\/\/neuropediatoolkit.org\/?p=7990"},"modified":"2026-09-24T15:33:32","modified_gmt":"2026-09-24T15:33:32","slug":"kcnx-databases","status":"publish","type":"post","link":"https:\/\/neuropediatoolkit.org\/ja\/kcnx-databases\/","title":{"rendered":"KCNx \u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3002"},"content":{"rendered":"<h2>KCNx \u30c7\u30fc\u30bf\u30d9\u30fc\u30b9: \u5c0f\u5150\u671f\u306e\u795e\u7d4c\u75be\u60a3\u306e\u8a3a\u65ad\u3068\u7ba1\u7406\u306b\u4e0d\u53ef\u6b20\u306a\u30c4\u30fc\u30eb<\/h2>\n<p>KCNx \u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306f\u3001\u5c0f\u5150\u795e\u7d4c\u907a\u4f1d\u5b66\u306e\u5206\u91ce\u3067\u6700\u3082\u9ad8\u5ea6\u3067\u7279\u6b8a\u306a\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u306e 1 \u3064\u3067\u3042\u308a\u3001\u7279\u306b KCNx \u578b\u30ab\u30ea\u30a6\u30e0 \u30c1\u30e3\u30cd\u30eb (K<sub>+<\/sub> \u30c1\u30e3\u30cd\u30eb\u3001\u96fb\u4f4d\u4f9d\u5b58\u6027\u3001\u30b5\u30d6\u30d5\u30a1\u30df\u30ea\u30fc ClinVar \u3084 OMIM \u306a\u3069\u306e\u4e00\u822c\u7684\u306a\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3068\u306f\u7570\u306a\u308a\u3001KCNx \u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306f\u3001\u767a\u9054\u4e2d\u306e\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306b\u304a\u3051\u308b\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u8208\u596e\u6027\u3001\u30b7\u30ca\u30d7\u30b9\u5f62\u6210\u3001\u76ae\u8cea\u767a\u9054\u3001\u304a\u3088\u3073\u7d30\u80de\u5185\u30ab\u30ea\u30a6\u30e0\u6052\u5e38\u6027\u306e\u8abf\u7bc0\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u30ab\u30ea\u30a6\u30e0 \u30c1\u30e3\u30cd\u30eb\u306e\u30d5\u30a1\u30df\u30ea\u30fc\u306b\u306e\u307f\u7126\u70b9\u3092\u5f53\u3066\u3066\u3044\u308b\u70b9\u3067\u533a\u5225\u3055\u308c\u307e\u3059\u3002\u3053\u306e\u5c02\u9580\u5316\u306b\u3088\u308a\u3001\u795e\u7d4c\u5c0f\u5150\u79d1\u533b\u3084\u81e8\u5e8a\u907a\u4f1d\u5b66\u8005\u306f\u5909\u7570\u3092\u7279\u5b9a\u3059\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u305d\u306e\u6a5f\u80fd\u7684\u304a\u3088\u3073\u81e8\u5e8a\u7684\u5f71\u97ff\u3092\u524d\u4f8b\u306e\u306a\u3044\u7cbe\u5ea6\u3067\u4e88\u6e2c\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u3053\u306e\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306f\u907a\u4f1d\u60c5\u5831\u3092\u4fdd\u5b58\u3059\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u7db2\u819c\u96fb\u56f3\u691c\u67fb\u3001\u30c8\u30e9\u30f3\u30b9\u30b8\u30a7\u30cb\u30c3\u30af\u30de\u30a6\u30b9\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u30d1\u30c3\u30c1\u30af\u30e9\u30f3\u30d7\u3001\u30d2\u30c8\u80ce\u5150\u8133\u7d44\u7e54\u306e\u767a\u73fe\u7814\u7a76\u3001\u30cb\u30e5\u30fc\u30ed\u30f3\u30aa\u30eb\u30ac\u30ce\u30a4\u30c9\u30e2\u30c7\u30eb\u306e\u5909\u7570\u89e3\u6790\u3092\u901a\u3058\u3066\u5f97\u3089\u308c\u305f\u6a5f\u80fd\u30c7\u30fc\u30bf\u3082\u7d71\u5408\u3057\u3066\u304a\u308a\u3001\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u306e\u81e8\u5e8a\u610f\u601d\u6c7a\u5b9a\u30c4\u30fc\u30eb\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u75c5\u614b\u751f\u7406\u5b66\u7684\u89b3\u70b9\u304b\u3089\u3001KCNx \u30c1\u30e3\u30cd\u30eb\u306f\u795e\u7d4c\u819c\u306e\u518d\u5206\u6975\u3068\u819c\u96fb\u4f4d\u306e\u8abf\u7bc0\u306b\u4e0d\u53ef\u6b20\u3067\u3059\u3002\u305d\u306e\u6a5f\u80fd\u4e0d\u5168\u306f\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u904e\u5270\u8208\u596e\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u305d\u306e\u7d50\u679c\u3001\u3066\u3093\u304b\u3093\u3001\u4e00\u6642\u7684\u306a\u9ebb\u75fa\u3001\u904b\u52d5\u5931\u8abf\u3001\u307e\u305f\u306f\u795e\u7d4c\u5fc3\u7406\u5b66\u7684\u767a\u9054\u969c\u5bb3\u304c\u5f15\u304d\u8d77\u3053\u3055\u308c\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u3001\u6b21\u306e\u3088\u3046\u306a\u7a81\u7136\u5909\u7570\u304c\u3042\u308a\u307e\u3059\u3002 <em>KCN1<\/em> (Kv1.1) \u306f\u3001\u904b\u52d5\u5931\u8abf\u304a\u3088\u3073\u9ebb\u75fa\u75c7\u5019\u7fa4 (EA1) \u306e\u30a8\u30d4\u30bd\u30fc\u30c9\u3068\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002EA1 \u306f\u3001\u5c0f\u5150\u671f\u306b\u77ed\u671f\u9593\u306e\u904b\u52d5\u5931\u8abf\u3001\u9707\u3048\u3001\u304a\u3088\u3073\u5834\u5408\u306b\u3088\u3063\u3066\u306f\u90e8\u5206\u767a\u4f5c\u3092\u4f34\u3046\u5e38\u67d3\u8272\u4f53\u512a\u6027\u75be\u60a3\u3067\u3059\u3002 KCNx \u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306f\u3001\u5909\u7570\u306e\u6b63\u78ba\u306a\u4f4d\u7f6e (S4 \u819c\u8cab\u901a\u30c9\u30e1\u30a4\u30f3\u306a\u3069) \u3060\u3051\u3067\u306a\u304f\u3001\u30ab\u30ea\u30a6\u30e0\u306e\u900f\u904e\u6027\u3001\u6d3b\u6027\u5316\u6642\u9593\u3001\u4e0d\u6d3b\u5316\u3001\u56de\u5fa9\u3092\u5909\u5316\u3055\u305b\u308b\u304b\u3069\u3046\u304b\u306a\u3069\u3001\u305d\u306e\u6a5f\u80fd\u7684\u5206\u985e\u3082\u63d0\u4f9b\u3057\u307e\u3059\u3002\u3067\u767a\u8868\u3055\u308c\u305f\u6700\u8fd1\u306e\u7814\u7a76 <em>\u81ea\u7136\u795e\u7d4c\u79d1\u5b66<\/em> (2023) \u306f\u3001\u7279\u5b9a\u306e\u5909\u7570\u4f53\u3067\u3042\u308b\u3053\u3068\u3092\u5b9f\u8a3c\u3057\u307e\u3057\u305f\u3002 <em>KCN1<\/em> \u3053\u308c\u3089\u306f\u3001AD1 \u306e\u5c0f\u5150\u306b\u304a\u3051\u308b\u767a\u4f5c\u306e\u983b\u5ea6\u306e\u9ad8\u3055\u3068\u76f8\u95a2\u3059\u308b\u6a5f\u80fd\u55aa\u5931\u3092\u5f15\u304d\u8d77\u3053\u3059\u305f\u3081\u3001\u81e8\u5e8a\u533b\u306f\u30a2\u30bb\u30bf\u30be\u30e9\u30df\u30c9\u3084\u30e9\u30e2\u30c8\u30ea\u30b8\u30f3\u306a\u3069\u306e\u819c\u5b89\u5b9a\u5316\u85ac\u306b\u3088\u308b\u6cbb\u7642\u3092\u3088\u308a\u6b63\u78ba\u306b\u8abf\u6574\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>\u5c0f\u5150\u79d1\u306e\u5206\u91ce\u3067\u306f\u3001KCNx \u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306f\u3001\u82e5\u5e74\u6027\u3066\u3093\u304b\u3093\u3001\u81ea\u9589\u75c7\u30b9\u30da\u30af\u30c8\u30e9\u30e0\u969c\u5bb3 (ASD)\u3001\u7b4b\u7dca\u5f35\u4f4e\u4e0b\u307e\u305f\u306f\u75d9\u7e2e\u3092\u4f34\u3046\u767a\u9054\u9045\u5ef6\u75c7\u5019\u7fa4\u306e\u9451\u5225\u8a3a\u65ad\u306b\u7279\u306b\u4fa1\u5024\u304c\u3042\u308a\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u3001\u6b21\u306e\u3088\u3046\u306a\u7a81\u7136\u5909\u7570\u304c\u3042\u308a\u307e\u3059\u3002 <em>KCN2<\/em> (Kv2.1) \u306f\u3001\u9032\u884c\u6027\u8133\u75c7\u3001\u91cd\u5ea6\u306e\u7b4b\u7dca\u5f35\u4f4e\u4e0b\u3001\u5fc3\u62cd\u30ea\u30ba\u30e0\u7570\u5e38 (\u95a2\u9023\u3059\u308b\u30d6\u30eb\u30ac\u30c0\u75c7\u5019\u7fa4) \u306a\u3069\u306e\u8868\u73fe\u578b\u3092\u4f34\u3046\u65b0\u751f\u5150\u767a\u75c7\u3066\u3093\u304b\u3093\u3068\u95a2\u9023\u4ed8\u3051\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3092\u4f7f\u7528\u3059\u308b\u3068\u3001\u81e8\u5e8a\u533b\u306f\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u306b\u76f4\u63a5\u7d71\u5408\u3055\u308c\u3066\u3044\u308b CADD\u3001REVEL\u3001PolyPhen-2 \u306a\u3069\u306e\u4e88\u6e2c\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u3092\u4f7f\u7528\u3057\u3066\u3001\u60a3\u8005\u3067\u898b\u3064\u304b\u3063\u305f\u5909\u7570\u3092\u65e2\u77e5\u306e\u75c5\u539f\u6027\u306e\u5909\u7570\u306e\u30bb\u30c3\u30c8\u3068\u6bd4\u8f03\u3067\u304d\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u80ce\u5150\u306e\u8133\u306e\u7d44\u7e54\u767a\u73fe\u30c7\u30fc\u30bf\uff08BrainSpan \u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306b\u3088\u308b\uff09\u3078\u306e\u30a2\u30af\u30bb\u30b9\u3082\u63d0\u4f9b\u3059\u308b\u305f\u3081\u3001\u598a\u5a20 12 \u9031\u304b\u3089 20 \u9031\u306e\u9593\u306e\u524d\u982d\u524d\u91ce\u306e\u5f62\u6210\u306a\u3069\u3001\u8133\u306e\u767a\u9054\u306e\u7279\u5b9a\u306e\u6bb5\u968e\u3067\u767a\u73fe\u304c\u91cd\u8981\u306a\u30c1\u30e3\u30cd\u30eb\u306b\u5909\u7570\u304c\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u304b\u3069\u3046\u304b\u3092\u8a55\u4fa1\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>KCNx \u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u5185\u306e\u60c5\u5831\u306e\u4e3b\u306a\u30ab\u30c6\u30b4\u30ea\u3092\u793a\u3059\u30d5\u30ed\u30fc\u30c1\u30e3\u30fc\u30c8 (\u6dfb\u4ed8\u56f3) \u306f\u3001\u5358\u306a\u308b\u60c5\u5831\u63d0\u4f9b\u3067\u306f\u306a\u304f\u3001\u5bfe\u8a71\u578b\u306e\u81e8\u5e8a\u30ac\u30a4\u30c9\u3067\u3059\u3002\u5404\u5206\u5c90\u306f\u8a55\u4fa1\u8ef8\u3092\u8868\u3057\u307e\u3059\u3002 <strong>\u907a\u4f1d\u5b66<\/strong> \u3053\u308c\u306b\u306f\u3001\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u914d\u5217\u3068\u5909\u7570\u306e\u5206\u985e (\u826f\u6027\u3001\u304a\u305d\u3089\u304f\u75c5\u539f\u6027\u3001\u75c5\u539f\u6027) \u3060\u3051\u3067\u306a\u304f\u3001\u5236\u5fa1\u3055\u308c\u305f\u96c6\u56e3\u306b\u304a\u3051\u308b\u983b\u5ea6 (1000 \u30b2\u30ce\u30e0\u3001gnomAD)\u3001\u907a\u4f1d (\u5e38\u67d3\u8272\u4f53\u512a\u6027\u3001\u52a3\u6027\u3001X \u9023\u9396)\u3001\u304a\u3088\u3073\u8868\u73fe\u578b\u306e\u6d78\u900f\u5ea6\u3082\u542b\u307e\u308c\u307e\u3059\u3002\u652f\u5e97 <strong>\u69cb\u9020<\/strong> \u3053\u308c\u306b\u3088\u308a\u3001\u30ab\u30ea\u30a6\u30e0\u7d50\u5408\u30c9\u30e1\u30a4\u30f3\uff08\u9078\u629e\u30d5\u30a3\u30eb\u30bf\u30fc\u306a\u3069\uff09\u306e\u5909\u7570\u304c\u3069\u306e\u3088\u3046\u306b\u30a4\u30aa\u30f3\u306e\u901a\u904e\u3092\u30d6\u30ed\u30c3\u30af\u3059\u308b\u304b\u3092\u8996\u899a\u5316\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u652f\u5e97 <strong>\u7279\u5fb4<\/strong> \u3053\u308c\u306b\u306f\u3001\u7570\u7a2e\u767a\u73fe\u7cfb\u3067\u5f97\u3089\u308c\u305f\u96fb\u6d41-\u96fb\u5727\u66f2\u7dda\u304a\u3088\u3073\u4e0d\u6d3b\u5316\u6642\u9593\u4ed8\u304d\u306e\u96fb\u6c17\u6d3b\u6027\u30c7\u30fc\u30bf\u304c\u542b\u307e\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u306b\u3088\u308a\u3001\u7a81\u7136\u5909\u7570\u304c\u6a5f\u80fd\u306e\u7372\u5f97\u307e\u305f\u306f\u55aa\u5931\u3092\u5f15\u304d\u8d77\u3053\u3059\u304b\u3069\u3046\u304b\u3092\u4e88\u6e2c\u3067\u304d\u307e\u3059\u3002\u5178\u578b\u7684\u306a\u81e8\u5e8a\u4f8b: \u90e8\u5206\u767a\u4f5c\u3068\u9032\u884c\u6027\u904b\u52d5\u5931\u8abf\u3092\u60a3\u3046\u751f\u5f8c 18 \u304b\u6708\u306e\u5b50\u4f9b\u3002\u305d\u306e\u30a8\u30af\u30bd\u30fc\u30e0\u306b\u3088\u308a\u8eab\u4f53\u306e\u5909\u7570\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002 <em>KCN13<\/em> (Kv13)\u3002 KCNx \u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3092\u8abf\u3079\u308b\u3068\u3001\u3053\u306e\u5909\u7570\u4f53\u306f S6 \u30c9\u30e1\u30a4\u30f3\u306b\u4f4d\u7f6e\u3057\u3001\u523a\u6fc0\u6761\u4ef6\u4e0b\u3067\u30ab\u30ea\u30a6\u30e0\u96fb\u6d41\u304c 70% \u6e1b\u5c11\u3059\u308b\u3053\u3068\u304c\u89b3\u5bdf\u3055\u308c\u3001\u6a5f\u80fd\u306e\u55aa\u5931\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u81e8\u5e8a\u30c1\u30fc\u30e0\u306f\u3001\u30ec\u30c1\u30ac\u30d3\u30f3\u306a\u3069\u306e\u4ee3\u66ff\u30ab\u30ea\u30a6\u30e0\u30c1\u30e3\u30cd\u30eb\u306e\u6d3b\u6027\u3092\u9ad8\u3081\u308b\u85ac\u5264\u306b\u3088\u308b\u6cbb\u7642\u306b\u5411\u304b\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059\uff08\u305f\u3060\u3057\u30012\u6b73\u672a\u6e80\u306e\u5c0f\u5150\u3078\u306e\u4f7f\u7528\u306b\u306f\u526f\u4f5c\u7528\u306e\u305f\u3081\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\uff09\u3002<\/p>\n<p>\u3055\u3089\u306b\u3001KCNx \u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306b\u306f\u3001 <em>\u81e8\u5e8a\u76f8\u95a2<\/em> \u3053\u308c\u306b\u3088\u308a\u3001\u30e6\u30fc\u30b6\u30fc\u306f\u60a3\u8005\u306e\u8868\u73fe\u578b\u3092\u4ed6\u306e\u767b\u9332\u3055\u308c\u305f\u75c7\u4f8b\u3068\u6bd4\u8f03\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u3001\u60a3\u8005\u304c\u65b0\u751f\u5150\u4f4e\u8840\u5727\u3001\u751f\u5f8c 1 \u304b\u6708\u4ee5\u5185\u306b\u767a\u75c7\u3059\u308b\u3066\u3093\u304b\u3093\u3001\u767a\u9054\u9045\u5ef6\u3092\u60a3\u3063\u3066\u3044\u308b\u5834\u5408\u3001\u30b7\u30b9\u30c6\u30e0\u306f\u6b21\u306e\u3088\u3046\u306a\u5909\u7570\u306e\u30ea\u30b9\u30c8\u3092\u63d0\u6848\u3067\u304d\u307e\u3059\u3002 <em>KCN1<\/em>, <em>KCN2<\/em>, <em>KCN11<\/em> (Kv11.1\u30012\u578bQT\u5ef6\u9577\u75c7\u5019\u7fa4\u304a\u3088\u3073\u3066\u3093\u304b\u3093\u306b\u95a2\u9023)\u3001\u307e\u305f\u306f <em>KCN15<\/em> (Kv15)\u3001\u8868\u73fe\u578b\u985e\u4f3c\u6027\u30b9\u30b3\u30a2\u4ed8\u304d\u3002\u3053\u306e\u6a5f\u80fd\u306f\u3001\u975e\u5b9a\u578b\u8868\u73fe\u578b\u3084\u7a00\u306a\u5909\u7570\u3092\u6301\u3064\u60a3\u8005\u306a\u3069\u3001\u8a3a\u65ad\u304c\u56f0\u96e3\u306a\u5834\u5408\u306b\u7279\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u9650\u754c\u3092\u8a8d\u8b58\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306b\u306f\u6587\u732e\u306b\u8a18\u8f09\u3055\u308c\u3066\u3044\u308b\u3059\u3079\u3066\u306e\u8868\u73fe\u578b\u304c\u307e\u3060\u542b\u307e\u308c\u3066\u304a\u3089\u305a\u3001\u6a5f\u80fd\u4e88\u6e2c\u306f\u5b9f\u9a13\u7684\u691c\u8a3c\u306b\u4ee3\u308f\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u8a3a\u65ad\u306b\u7591\u554f\u304c\u3042\u308b\u5834\u5408\u306b\u306f\u3001\u5b9f\u9a13\u5ba4\uff08\u7d30\u80de\u767a\u73fe\u7cfb\u306a\u3069\uff09\u3067\u306e\u6a5f\u80fd\u691c\u67fb\u3067\u5909\u7570\u3092\u78ba\u8a8d\u3059\u308b\u3053\u3068\u304c\u5e38\u306b\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/p>\n<figure class=\"wp-block-image size-full\">\n  <img fetchpriority=\"high\" decoding=\"async\" width=\"575\" height=\"407\" src=\"https:\/\/neuropediatoolkit.org\/wp-content\/uploads\/2025\/12\/image.png\" alt=\"Diagrama de flujo que muestra las principales categor\u00edas de informaci\u00f3n contenidas en el KCNx database: gen\u00e9tica, estructura y funciones.\" class=\"wp-image-7998\" srcset=\"https:\/\/neuropediatoolkit.org\/wp-content\/uploads\/2025\/12\/image.png 575w, https:\/\/neuropediatoolkit.org\/wp-content\/uploads\/2025\/12\/image-300x212.png 300w, https:\/\/neuropediatoolkit.org\/wp-content\/uploads\/2025\/12\/image-18x12.png 18w\" sizes=\"(max-width: 575px) 100vw, 575px\" \/><figcaption>KCNx \u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306b\u542b\u307e\u308c\u308b\u60c5\u5831\u306e\u4e3b\u306a\u30ab\u30c6\u30b4\u30ea (\u907a\u4f1d\u5b66\u3001\u69cb\u9020\u3001\u6a5f\u80fd) \u3092\u793a\u3059\u30d5\u30ed\u30fc\u30c1\u30e3\u30fc\u30c8\u3002\u5404\u30d6\u30e9\u30f3\u30c1\u306b\u3088\u308a\u3001\u907a\u4f1d\u5b50\u5909\u7570\u306e\u591a\u6b21\u5143\u8a55\u4fa1\u304c\u53ef\u80fd\u306b\u306a\u308a\u3001\u795e\u7d4c\u5c0f\u5150\u79d1\u306b\u304a\u3051\u308b\u9451\u5225\u8a3a\u65ad\u3068\u6cbb\u7642\u4e0a\u306e\u610f\u601d\u6c7a\u5b9a\u304c\u5bb9\u6613\u306b\u306a\u308a\u307e\u3059\u3002<\/figcaption><\/figure>\n<p>\u3064\u307e\u308a\u3001KCNx \u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306f\u5358\u306a\u308b\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3067\u306f\u306a\u304f\u3001\u795e\u7d4c\u5c0f\u5150\u79d1\u533b\u306e\u8a3a\u7642\u3092\u5909\u9769\u3059\u308b\u7d71\u5408\u81e8\u5e8a\u30a4\u30f3\u30c6\u30ea\u30b8\u30a7\u30f3\u30b9 \u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u3067\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u907a\u4f1d\u5b50\u8a3a\u65ad\u304b\u3089\u3001\u7cbe\u5bc6\u533b\u7642\u306e\u539f\u5247\u306b\u6cbf\u3063\u305f\u3001\u6a5f\u80fd\u7684\u3067\u500b\u5225\u5316\u3055\u308c\u305f\u30a2\u30d7\u30ed\u30fc\u30c1\u3078\u306e\u79fb\u884c\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002\u5c0f\u5150\u795e\u7d4c\u75be\u60a3\u306e\u8a3a\u65ad\u306b\u4f53\u7cfb\u7684\u306b\u4f7f\u7528\u3059\u308b\u3068\u3001\u8a3a\u65ad\u6642\u9593\u3092\u5927\u5e45\u306b\u77ed\u7e2e\u3057\u3001\u4e0d\u5fc5\u8981\u306a\u691c\u67fb\u3092\u56de\u907f\u3057\u3001\u3088\u308a\u52b9\u679c\u7684\u306a\u9078\u629e\u80a2\u306b\u6cbb\u7642\u3092\u5c0e\u304f\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u3053\u306e\u30c4\u30fc\u30eb\u306b\u30a2\u30af\u30bb\u30b9\u3059\u308b\u306b\u306f\u3001\u516c\u5f0f\u30dd\u30fc\u30bf\u30eb\u306b\u30a2\u30af\u30bb\u30b9\u3059\u308b\u3053\u3068\u3092\u304a\u52e7\u3081\u3057\u307e\u3059\u3002 <a href=\"https:\/\/kcnxdb.neuropediatoolkit.org\">KCNx \u30c7\u30fc\u30bf\u30d9\u30fc\u30b9 \u2013 \u30cb\u30e5\u30fc\u30ed\u30da\u30c7\u30a3\u30a2 \u30c4\u30fc\u30eb\u30ad\u30c3\u30c8<\/a>.<\/p>","protected":false},"excerpt":{"rendered":"<p>KCNx \u30c7\u30fc\u30bf\u30d9\u30fc\u30b9: \u5c0f\u5150\u306b\u304a\u3051\u308b\u795e\u7d4c\u75be\u60a3\u306e\u8a3a\u65ad\u3068\u7ba1\u7406\u306b\u4e0d\u53ef\u6b20\u306a\u30c4\u30fc\u30eb KCNx \u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306f\u3001\u5c0f\u5150\u795e\u7d4c\u907a\u4f1d\u5b66\u306e\u5206\u91ce\u3067\u6700\u3082\u5148\u9032\u7684\u3067\u7279\u6b8a\u306a\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u306e 1 \u3064\u3067\u3042\u308a\u3001\u7279\u306b KCNx \u30bf\u30a4\u30d7\u306e\u30ab\u30ea\u30a6\u30e0 \u30c1\u30e3\u30cd\u30eb (K+ \u30c1\u30e3\u30cd\u30eb\u3001\u96fb\u4f4d\u4f9d\u5b58\u6027\u30c1\u30e3\u30cd\u30eb\u3001\u30b5\u30d6\u30d5\u30a1\u30df\u30ea\u30fc...) \u306b\u95a2\u3059\u308b\u591a\u6b21\u5143\u30c7\u30fc\u30bf\u3092\u7d71\u5408\u304a\u3088\u3073\u6574\u7406\u3059\u308b\u3088\u3046\u306b\u8a2d\u8a08\u3055\u308c\u3066\u3044\u307e\u3059\u3002 <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/neuropediatoolkit.org\/ja\/kcnx-databases\/\" class=\"more-link\">\u7d9a\u304d\u3092\u8aad\u3080<span class=\"screen-reader-text\"> \u300cKCNx \u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u300d<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":7998,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[4],"tags":[],"class_list":["post-7990","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-epilepsia","entry"],"_links":{"self":[{"href":"https:\/\/neuropediatoolkit.org\/ja\/wp-json\/wp\/v2\/posts\/7990","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/neuropediatoolkit.org\/ja\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/neuropediatoolkit.org\/ja\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/ja\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/ja\/wp-json\/wp\/v2\/comments?post=7990"}],"version-history":[{"count":5,"href":"https:\/\/neuropediatoolkit.org\/ja\/wp-json\/wp\/v2\/posts\/7990\/revisions"}],"predecessor-version":[{"id":8723,"href":"https:\/\/neuropediatoolkit.org\/ja\/wp-json\/wp\/v2\/posts\/7990\/revisions\/8723"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/ja\/wp-json\/wp\/v2\/media\/7998"}],"wp:attachment":[{"href":"https:\/\/neuropediatoolkit.org\/ja\/wp-json\/wp\/v2\/media?parent=7990"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/ja\/wp-json\/wp\/v2\/categories?post=7990"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/neuropediatoolkit.org\/ja\/wp-json\/wp\/v2\/tags?post=7990"}],"curies":[{"name":"\u3046\u30fc\u3093","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}