Historia y descubrimiento.
Farmacocinética.
Farmacodinámica.
Uso clínico.
Empeoramiento de las crisis por AED.
332710
{332710:47I3GEK8},{332710:MMUZB9S4}
1
vancouver
50
default
5748
https://neuropediatoolkit.org/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%2247I3GEK8%22%2C%22library%22%3A%7B%22id%22%3A332710%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Genton%22%2C%22parsedDate%22%3A%222000-03%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EGenton%20P.%20When%20antiepileptic%20drugs%20aggravate%20epilepsy.%20Brain%20Dev.%202000%20Mar%3B22%282%29%3A75%26%23x2013%3B80.%3C%5C%2Fdiv%3E%5Cn%20%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22When%20antiepileptic%20drugs%20aggravate%20epilepsy%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22Genton%22%7D%5D%2C%22abstractNote%22%3A%22Paradoxically%2C%20an%20antiepileptic%20drug%20%28AED%29%20may%20aggravate%20epilepsy.%20The%20number%20of%20AEDs%20is%20steadily%20increasing%2C%20and%20the%20occurrence%20of%20paradoxical%20aggravation%20will%20probably%20become%20a%20frequent%20problem.%20The%20overall%20status%20of%20the%20patient%20treated%20for%20epilepsy%20can%20be%20altered%20due%20to%20maladjustment%20to%20the%20diagnosis%20of%20epilepsy%2C%20to%20unwanted%20side-effects%2C%20to%20overdosage%20and%20to%20the%20occurrence%20of%20tolerance.%20However%2C%20the%20main%20mechanism%20of%20aggravation%20is%20the%20occurrence%20of%20an%20inverse%20pharmacodynamic%20effect.%20The%20specific%20effect%20of%20the%20AED%20is%20such%20that%20it%20controls%20epilepsy%20in%20most%20cases%20and%20increases%20seizures%20in%20other%20cases.%20Idiopathic%20generalised%20epilepsies%20%28IGE%29%20are%20particularly%20prone%20to%20pharmacodynamic%20aggravation%3A%20typical%20absences%20are%20constantly%20increased%20by%20carbamazepine%20%28CBZ%29%2C%20vigabatrin%2C%20tiagabine%2C%20gabapentin%2C%20while%20phenytoin%20%28PHT%29%20is%20less%20aggravating.%20Juvenile%20myoclonic%20epilepsy%20is%20often%20aggravated%20by%20CBZ%2C%20less%20constantly%20by%20PHT%20and%20other%20AEDs.%20Generalised%20tonic-clonic%20seizures%20found%20in%20IGEs%20may%20respond%20to%20AEDs%20that%20aggravate%20the%20other%20seizure%20types.%20In%20symptomatic%20generalised%20epilepsies%2C%20patients%20have%20often%20several%20seizure%20types%20that%20respond%20differently%20to%20AEDs%3A%20myoclonias%20are%20generally%20aggravated%20by%20the%20same%20drugs%20that%20aggravated%20IGEs%3B%20tonic%20seizures%20in%20the%20Lennox-Gastaut%20syndrome%20respond%20to%20CBZ%2C%20which%20may%20however%20aggravate%20atypical%20absences.%20In%20severe%20myoclonic%20epilepsy%20of%20infancy%2C%20there%20is%20a%20nearly%20constant%20aggravating%20effect%20of%20lamotrigine.%20In%20some%20patients%20with%20benign%20rolandic%20epilepsy%2C%20a%20clear%20aggravation%20may%20be%20produced%20by%20CBZ%2C%20with%20occurrence%20of%20negative%20myoclonias%2C%20atypical%20absences%2C%20drop%20attacks%2C%20and%20at%20the%20maximum%20evolution%20into%20a%20state%20of%20electrical%20status%20epilepticus%20during%20sleep.%20It%20is%20much%20more%20difficult%20to%20pinpoint%20specific%20pharmacological%20sensitivity%20in%20other%20focal%20epilepsies%2C%20but%20aggravation%20clearly%20occurs.%20When%20treating%20epilepsy%2C%20the%20clinician%20should%20act%20according%20to%20seizure%20type%2C%20or%2C%20better%2C%20to%20epilepsy%20type.%20Patients%20are%20usually%20aware%20of%20aggravation%20before%20their%20doctors%3A%20we%20should%20listen%20carefully%20whenever%20they%20express%20a%20%27dislike%27%20for%20an%20AED.%22%2C%22date%22%3A%222000-03%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fs0387-7604%2899%2900113-8%22%2C%22ISSN%22%3A%220387-7604%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22CWWAV89W%22%5D%2C%22dateModified%22%3A%222024-02-07T19%3A15%3A09Z%22%7D%7D%2C%7B%22key%22%3A%22MMUZB9S4%22%2C%22library%22%3A%7B%22id%22%3A332710%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ong%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EOng%20LC.%20Seizures%20exacerbated%20by%20antiepileptic%20drugs%20in%20children.%3C%5C%2Fdiv%3E%5Cn%20%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Seizures%20exacerbated%20by%20antiepileptic%20drugs%20in%20children%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lai%20Choo%22%2C%22lastName%22%3A%22Ong%22%7D%5D%2C%22abstractNote%22%3A%22There%20is%20growing%20evidence%20that%20antiepileptic%20drugs%20used%20in%20children%20that%20are%20meant%20to%20control%20seizures%20can%20actually%20cause%20seizure%20exacerbate%20instead.%20To%20minimize%20this%20problem%2C%20clinicians%20should%20be%20familiar%20with%20the%20epilepsy%20syndromes%20and%20the%20appropriate%20choice%20of%20antiepileptic%20drugs%2C%20avoid%20certain%20antiepileptic%20drugs%20which%20consistently%20aggravate%20speci%5Cufb01c%20seizure%20types%20and%20maintain%20a%20high%20index%20of%20suspicion%20of%20those%20at%20high%20risk%20as%20seizure%20exacerbation%20can%20present%20in%20diverse%20forms.%22%2C%22date%22%3A%22%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%22%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22CWWAV89W%22%5D%2C%22dateModified%22%3A%222024-02-07T19%3A14%3A59Z%22%7D%7D%5D%7D
1.
Genton P. When antiepileptic drugs aggravate epilepsy. Brain Dev. 2000 Mar;22(2):75–80.
1.
Ong LC. Seizures exacerbated by antiepileptic drugs in children.