
332710
{332710:Y28NDTWQ}
1
vancouver
50
default
4957
https://neuropediatoolkit.org/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22Y28NDTWQ%22%2C%22library%22%3A%7B%22id%22%3A332710%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Nikitina%20et%20al.%22%2C%22parsedDate%22%3A%222021-02-22%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3ENikitina%20TV%2C%20Kashevarova%20AA%2C%20Gridina%20MM%2C%20Lopatkina%20ME%2C%20Khabarova%20AA%2C%20Yakovleva%20YS%2C%20et%20al.%20Complex%20biology%20of%20constitutional%20ring%20chromosomes%20structure%20and%20%28in%29stability%20revealed%20by%20somatic%20cell%20reprogramming.%20Sci%20Rep%20%5BInternet%5D.%202021%20Feb%2022%20%5Bcited%202023%20Mar%2012%5D%3B11%281%29%3A4325.%20Available%20from%3A%20%3Ca%20class%3D%27zp-ItemURL%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41598-021-83399-3%27%3Ehttps%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41598-021-83399-3%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Complex%20biology%20of%20constitutional%20ring%20chromosomes%20structure%20and%20%28in%29stability%20revealed%20by%20somatic%20cell%20reprogramming%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22T.%20V.%22%2C%22lastName%22%3A%22Nikitina%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%20A.%22%2C%22lastName%22%3A%22Kashevarova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%20M.%22%2C%22lastName%22%3A%22Gridina%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%20E.%22%2C%22lastName%22%3A%22Lopatkina%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%20A.%22%2C%22lastName%22%3A%22Khabarova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yu%20S.%22%2C%22lastName%22%3A%22Yakovleva%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%20G.%22%2C%22lastName%22%3A%22Menzorov%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yu%20A.%22%2C%22lastName%22%3A%22Minina%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22I.%20E.%22%2C%22lastName%22%3A%22Pristyazhnyuk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%20A.%22%2C%22lastName%22%3A%22Vasilyev%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.%20A.%22%2C%22lastName%22%3A%22Fedotov%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22O.%20L.%22%2C%22lastName%22%3A%22Serov%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22I.%20N.%22%2C%22lastName%22%3A%22Lebedev%22%7D%5D%2C%22abstractNote%22%3A%22Human%20ring%20chromosomes%20are%20often%20unstable%20during%20mitosis%2C%20and%20daughter%20cells%20can%20be%20partially%20or%20completely%20aneuploid.%20We%20studied%20the%20mitotic%20stability%20of%20four%20ring%20chromosomes%2C%208%2C%2013%2C%2018%2C%20and%2022%2C%20in%20long-term%20cultures%20of%20skin%20fibroblasts%20and%20induced%20pluripotent%20stem%20cells%20%28iPSCs%29%20by%20GTG%20karyotyping%20and%20aCGH.%20Ring%20chromosome%20loss%20and%20secondary%20aberrations%20were%20observed%20in%20all%20fibroblast%20cultures%20except%20for%20r%2818%29.%20We%20found%20monosomy%2C%20fragmentation%2C%20and%20translocation%20of%20indexed%20chromosomes.%20In%20iPSCs%2C%20aCGH%20revealed%20striking%20differences%20in%20mitotic%20stability%20both%20between%20iPSC%20lines%20with%20different%20rings%20and%2C%20in%20some%20cases%2C%20between%20cell%20lines%20with%20the%20same%20ring%20chromosome.%20We%20registered%20the%20spontaneous%20rescue%20of%20karyotype%2046%2CXY%2Cr%288%29%20to%2046%2CXY%20in%20all%20six%20iPSC%20lines%20through%20ring%20chromosome%20loss%20and%20intact%20homologue%20duplication%20with%20isoUPD%288%29pat%20occurrence%2C%20as%20proven%20by%20SNP%20genotype%20distribution%20analysis.%20In%20iPSCs%20with%20other%20ring%20chromosomes%2C%20karyotype%20correction%20was%20not%20observed.%20Our%20results%20suggest%20that%20spontaneous%20correction%20of%20the%20karyotype%20with%20ring%20chromosomes%20in%20iPSCs%20is%20not%20universal%20and%20that%20pluripotency%20is%20compatible%20with%20a%20wide%20range%20of%20derivative%20karyotypes.%20We%20conclude%20that%20marked%20variability%20in%20the%20frequency%20of%20secondary%20rearrangements%20exists%20in%20both%20fibroblast%20and%20iPSC%20cultures%2C%20expanding%20the%20clinical%20significance%20of%20the%20constitutional%20ring%20chromosome.%22%2C%22date%22%3A%222021-02-22%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41598-021-83399-3%22%2C%22ISSN%22%3A%222045-2322%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41598-021-83399-3%22%2C%22collections%22%3A%5B%22BXZ6JMC2%22%5D%2C%22dateModified%22%3A%222024-09-08T23%3A11%3A23Z%22%7D%7D%5D%7D
1.
Nikitina TV, Kashevarova AA, Gridina MM, Lopatkina ME, Khabarova AA, Yakovleva YS, et al. Complex biology of constitutional ring chromosomes structure and (in)stability revealed by somatic cell reprogramming. Sci Rep [Internet]. 2021 Feb 22 [cited 2023 Mar 12];11(1):4325. Available from: https://www.nature.com/articles/s41598-021-83399-3