CDC diagnostic algorithm and geographic areas affected by Zika virus outbreaks.
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statussuccessupdateneededfalseinstancefalsemetarequest_last0request_next0used_cachetruedatakeySLTNBH8Zlibraryid19955111metacreatorSummaryMooreetal.parsedDate2017-03-01numChildren1bibltdivclassquotcsl-bib-bodyquotstylequotline-height1.35quotgtnltdivclassquotcsl-entryquotstylequotclearleftquotgtnltdivclassquotcsl-left-marginquotstylequotfloatleftpadding-right0.5emtext-alignrightwidth1emquotgt1.ltdivgtltdivclassquotcsl-right-inlinequotstylequotmargin0.4em01.5emquotgtMooreCAStaplesJEDobynsWBPessoaAVenturaCVFonsecaEBdaetal.CharacterizingthePatternofAnomaliesinCongenitalZikaSyndromeforPediatricClinicians.JAMAPediatricsInternet.2017Mar1cited2022Oct151713288x201395.Availablefromltaclass039zp-ItemURL039href039httpsdoi.org10.1001jamapediatrics.2016.3982039gthttpsdoi.org10.1001jamapediatrics.2016.3982ltagtltdivgtnltdivgtnltdivgtdataitemTypejournalArticletitleCharacterizingthePatternofAnomaliesinCongenitalZikaSyndromeforPediatricClinicianscreatorscreatorTypeauthorfirstNameCynthiaA.lastNameMoorecreatorTypeauthorfirstNameJ.ErinlastNameStaplescreatorTypeauthorfirstNameWilliamB.lastNameDobynscreatorTypeauthorfirstNameAndru00e9lastNamePessoacreatorTypeauthorfirstNameCamilaV.lastNameVenturacreatorTypeauthorfirstNameEduardoBorgesdalastNameFonsecacreatorTypeauthorfirstNameErlaneMarqueslastNameRibeirocreatorTypeauthorfirstNameLianaO.lastNameVenturacreatorTypeauthorfirstNameNorbertoNogueiralastNameNetocreatorTypeauthorfirstNameJ.FernandolastNameArenacreatorTypeauthorfirstNameSonjaA.lastNameRasmussenabstractNoteZikavirusinfectioncanbeprenatallypassedfromapregnantwomantoherfetus.ThereissufficientevidencetoconcludethatintrauterineZikavirusinfectionisacauseofmicrocephalyandseriousbrainanomaliesbutthefullspectrumofanomalieshasnotbeendelineated.ToinformpediatricclinicianswhomaybecalledontoevaluateandtreataffectedinfantsandchildrenwereviewthemostrecentevidencetobettercharacterizecongenitalZikasyndrome.Wereviewedpublishedreportsofcongenitalanomaliesoccurringinfetusesorinfantswithpresumedorlaboratory-confirmedintrauterineZikavirusinfection.WeconductedacomprehensivesearchoftheEnglishliteratureusingMedlineandEMBASEforZikafrominceptionthroughSeptember302016.Congenitalanomalieswereconsideredinthecontextofthepresumedpathogeneticmechanismrelatedtotheneurotropicpropertiesofthevirus.WeconcludethatcongenitalZikasyndromeisarecognizablepatternofstructuralanomaliesandfunctionaldisabilitiessecondarytocentralandperhapsperipheralnervoussystemdamage.Althoughmanyofthecomponentsofthissyndromesuchascognitivesensoryandmotordisabilitiesaresharedbyothercongenitalinfectionsthereare5featuresthatarerarelyseenwithothercongenitalinfectionsorareuniquetocongenitalZikavirusinfection1severemicrocephalywithpartiallycollapsedskull2thincerebralcorticeswithsubcorticalcalcifications3macularscarringandfocalpigmentaryretinalmottling4congenitalcontracturesand5markedearlyhypertoniaandsymptomsofextrapyramidalinvolvement.AlthoughthefullspectrumofadversereproductiveoutcomescausedbyZikavirusinfectionisnotyetdeterminedadistinctivephenotypeu2014thecongenitalZikasyndromeu2014hasemerged.Recognitionofthisphenotypebycliniciansforinfantsandchildrencanhelpensureappropriateetiologicevaluationandcomprehensiveclinicalinvestigationtodefinetherangeofanomaliesinanaffectedinfantaswellasdetermineessentialfollow-upandongoingcare.date2017-03-01sectionpartNumberpartTitleDOI10.1001jamapediatrics.2016.3982citationKeyurlhttpsdoi.org10.1001jamapediatrics.2016.3982PMIDPMCIDISSN2168-6203languagecollectionsLSRDI9Z3dateModified2026-07-15T224031ZkeyP5CZDC4Ulibraryid19955111metacreatorSummaryAdebanjoparsedDate2017numChildren1bibltdivclassquotcsl-bib-bodyquotstylequotline-height1.35quotgtnltdivclassquotcsl-entryquotstylequotclearleftquotgtnltdivclassquotcsl-left-marginquotstylequotfloatleftpadding-right0.5emtext-alignrightwidth1emquotgt1.ltdivgtltdivclassquotcsl-right-inlinequotstylequotmargin0.4em01.5emquotgtAdebanjoT.UpdateInterimGuidancefortheDiagnosisEvaluationandManagementofInfantswithPossibleCongenitalZikaVirusInfectionx2014UnitedStatesOctober2017.MMWRMorbMortalWklyRepInternet.2017cited2022Oct1566.Availablefromltaclass039zp-ItemURL039href039httpswww.cdc.govmmwrvolumes66wrmm6641a1.htm039gthttpswww.cdc.govmmwrvolumes66wrmm6641a1.htmltagtltdivgtnltdivgtnltdivgtdataitemTypejournalArticletitleUpdateInterimGuidancefortheDiagnosisEvaluationandManagementofInfantswithPossibleCongenitalZikaVirusInfectionu2014UnitedStatesOctober2017creatorscreatorTypeauthorfirstNameTolulopelastNameAdebanjoabstractNoteCDChasupdateditsinterimguidanceforU.S.healthcareproviderscaringforinfantswithpossiblecongenitalZikavirusinfection1inresponsetorecentlypublishedupdatedguidance...date2017sectionpartNumberpartTitleDOI10.15585mmwr.mm6641a1citationKeyurlhttpswww.cdc.govmmwrvolumes66wrmm6641a1.htmPMIDPMCIDISSN0149-21951545-861Xlanguageen-uscollectionsLSRDI9Z3dateModified2026-05-09T194249Z
1.
Moore CA, Staples JE, Dobyns WB, Pessoa A, Ventura CV, Fonseca EB da, et al. Characterizing the Pattern of Anomalies in Congenital Zika Syndrome for Pediatric Clinicians. JAMA Pediatrics [Internet]. 2017 Mar 1 [cited 2022 Oct 15];171(3):288–95. Available from: https://doi.org/10.1001/jamapediatrics.2016.3982
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Adebanjo T. Update: Interim Guidance for the Diagnosis, Evaluation, and Management of Infants with Possible Congenital Zika Virus Infection — United States, October 2017. MMWR Morb Mortal Wkly Rep [Internet]. 2017 [cited 2022 Oct 15];66. Available from: https://www.cdc.gov/mmwr/volumes/66/wr/mm6641a1.htm