19955111
{19955111:PAFZLE62},{19955111:MYSYGBKT}
1
vancouver
50
default
3174
https://neuropediatoolkit.org/wp-content/plugins/zotpress/
statussuccessupdateneededfalseinstancefalsemetarequest_last0request_next0used_cachetruedatakeyMYSYGBKTlibraryid19955111metacreatorSummaryCampistoletal.parsedDate2012numChildren1bibltdivclassquotcsl-bib-bodyquotstylequotline-height1.35quotgtnltdivclassquotcsl-entryquotstylequotclearleftquotgtnltdivclassquotcsl-left-marginquotstylequotfloatleftpadding-right0.5emtext-alignrightwidth1emquotgt1.ltdivgtltdivclassquotcsl-right-inlinequotstylequotmargin0.4em01.5emquotgtCampistolJGalvezHCazorlaAGMxE1lagaIIriondoMCusxEDV.DisfuncixF3nneurolxF3gicainducidaporbilirrubina.NeurologxEDaInternet.2012cited2022Oct25274202x201311.Availablefromltaclass039zp-ItemURL039href039httpslinkinghub.elsevier.comretrievepiiS0213485310001908039gthttpslinkinghub.elsevier.comretrievepiiS0213485310001908ltagtltdivgtnltdivgtnltdivgtdataitemTypejournalArticletitleDisfunciu00f3nneurolu00f3gicainducidaporbilirrubinacreatorscreatorTypeauthorfirstNameJ.lastNameCampistolcreatorTypeauthorfirstNameH.lastNameGalvezcreatorTypeauthorfirstNameA.Garcu00edalastNameCazorlacreatorTypeauthorfirstNameI.lastNameMu00e1lagacreatorTypeauthorfirstNameM.lastNameIriondocreatorTypeauthorfirstNameV.lastNameCusu00edabstractNoteIntroductionu2018u2018Kernicterusu2019u2019isatermcurrentlyusedtodescribebilirrubininducedbraininjuryintheneuro-pathologicalstudies.Thisisaconfusingtermandnowadayswepreferbilirrubinencephalopathyorbilirrubininducedneurologicaldysfunction.Theclinicalsignsvaryanditisclearlydecreasinginprevalenceindevelopedcountries.MaterialandmethodsWereviewaseriesof7patientswithbilirrubinencephalopathyandvariableneurologicalmanifestationswhowereseenintheNeuropaediatricDepartmentinthelast10years.Onlyonepatientdiedintheneonatalperiodwithhyperbilirubinaemiasepsisandmulti-organfailure.nResultsDiverseaetiologicalfactorswererelatedtohyperbilirubinaemia.Allpatientshadclinicalsymptomsduetohyperbilirubinaemia.NeuroimagingduringtheneonatalperiodshowedinvolvementofthenucleuspalliduswithhyperintensityinT1inthebrainMRscanasthemostconsistentufb01nding.Allthepatientswhosurviveddevelopedneurologicalsignsandwetrytocorrelatethemwithbiochemicalclinicalneuroimagingandneurophysiologicalparameters.nConclusionsAnincreaseinthenumberofpatientswithbilirrubinencephalopathyhasbeenobservedoverthelastfewyearsandweattempttoufb01ndoutthecauses.Theincreasedsurvivalofthelowbirthweightnewbornstheincreaseintheimmigrationpopulationandtheuseofdiagnosticneuroimagingcontributetothisincrease.Itisagreatchallengefortheneonatologistandforneuropaediatricianstopreventitsoccurrenceandtominimisetheeffectsofbilirrubinencephalopathy.date052012sectionpartNumberpartTitleDOI10.1016j.nrl.2010.03.013citationKeyurlhttpslinkinghub.elsevier.comretrievepiiS0213485310001908PMIDPMCIDISSN02134853languageescollectionsQEICD8LNdateModified2026-05-09T201512ZkeyPAFZLE62libraryid19955111metacreatorSummaryPichonetal.parsedDate2022-10-25numChildren2bibltdivclassquotcsl-bib-bodyquotstylequotline-height1.35quotgtnltdivclassquotcsl-entryquotstylequotclearleftquotgtnltdivclassquotcsl-left-marginquotstylequotfloatleftpadding-right0.5emtext-alignrightwidth1emquotgt1.ltdivgtltdivclassquotcsl-right-inlinequotstylequotmargin0.4em01.5emquotgtPichonJBLRiordanSMWatchkoJShapiroSM.TheNeurologicalSequelaeofNeonatalHyperbilirubinemiaDefinitionsDiagnosisandTreatmentoftheKernicterusSpectrumDisordersKSDs.CurrentPediatricReviewsInternet.2022Oct25cited2022Oct25133199x2013209.Availablefromltaclass039zp-ItemURL039href039httpswww.eurekaselect.comarticle85263039gthttpswww.eurekaselect.comarticle85263ltagtltdivgtnltdivgtnltdivgtdataitemTypejournalArticletitleTheNeurologicalSequelaeofNeonatalHyperbilirubinemiaDefinitionsDiagnosisandTreatmentoftheKernicterusSpectrumDisordersKSDscreatorscreatorTypeauthorfirstNameJean-BaptisteLelastNamePichoncreatorTypeauthorfirstNameSeanM.lastNameRiordancreatorTypeauthorfirstNameJonlastNameWatchkocreatorTypeauthorfirstNameStevenM.lastNameShapiroabstractNoteBackgroundDespiteitslengthyhistorythestudyofjaundicehyperbilirubinemiaandnkernicterussuffersfromalackofclarityandconsistencyinthekeytermsusedtodescribeboththenclinicalandpathophysiologicalnatureoftheseconditions.ForexamplethetermBilirubin-inducednNeurologicalDysfunctionBINDhasbeenusedtorefertoallneurologicalsequelaecausedbyexposurentohighlevelsofbilirubintoonlymildneurologicalsequelaeortoscoringsystemsthatnquantitatetheprogressivestagesofAcuteBilirubinEncephalopathyABE.nnnObjectiveWeseektoclarifyandsimplifyterminologybyintroducingdefiningandproposingnnewtermsanddiagnosticcriteriaforkernicterus.nnnMethodsWeproposeasystematicnomenclaturebasedonpathophysiologicalandclinicalcriterianpresentingalogicalargumentforeachterm.AcknowledgingobservationsthatkernicterusissymptomaticallynbroadanddiverseweproposetheuseoftheoverarchingtermKernicterusSpectrumnDisordersKSDstoencompassalltheneurologicalsequelaeofbilirubinneurotoxicityincludingnAcuteBilirubinNeurotoxicityABE.WefurthersuggestsubclassificationofKSDsbasedonthenprincipaldisablingfeaturesofkernicterusmotorauditory.FinallywesuggestthetermsubtlenKSDtodesignateachildwithahistoryofsignificantbilirubinneurotoxicitywithmildorsubtlendevelopmentaldelays.nnnResultsandConclusionWeconcludewithabriefdescriptionofthelimitedtreatmentscurrentlynavailableforKSDtherebyunderscoringtheimportanceoffurtherresearch.WebelievethatadoptingnasystematicnomenclatureforthespectrumofclinicalconsequencesofhyperbilirubinemiawillnhelpunifythefieldandpromotemoreeffectiveresearchinbothpreventionandtreatmentofKSDs.date2022-10-25154036sectionpartNumberpartTitleDOI10.21741573396313666170815100214citationKeyurlhttpswww.eurekaselect.comarticle85263PMIDPMCIDISSNlanguageencollectionsQEICD8LNdateModified2026-05-09T071522Z
1.
Campistol J, Galvez H, Cazorla AG, Málaga I, Iriondo M, Cusí V. Bilirubin-induced neurological dysfunction. Neurology [Internet]. 2012 [cited 2022 Oct 25];27(4):202–11. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0213485310001908
1.
Pichon JBL, Riordan SM, Watchko J, Shapiro SM. The Neurological Sequelae of Neonatal Hyperbilirubinemia: Definitions, Diagnosis and Treatment of the Kernicterus Spectrum Disorders (KSDs). Current Pediatric Reviews [Internet]. 2022 Oct 25 [cited 2022 Oct 25];13(3):199–209. Available from: https://www.eurekaselect.com/article/85263