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1.
Campistol J, Galvez H, Cazorla AG, Málaga I, Iriondo M, Cusí V. Disfunción neurológica inducida por bilirrubina. Neurología [Internet]. 2012 [cited 2022 Oct 25];27(4):202–11. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0213485310001908
1.
Pichon JBL, Riordan SM, Watchko J, Shapiro SM. The Neurological Sequelae of Neonatal Hyperbilirubinemia: Definitions, Diagnosis and Treatment of the Kernicterus Spectrum Disorders (KSDs). Current Pediatric Reviews [Internet]. [cited 2022 Oct 25];13(3):199–209. Available from: https://www.eurekaselect.com/article/85263