Table 2. Overview of Indicators for Genetic Cerebral Palsy
Strong Moderate Possible 1.Dyskinesia∗ ∗ 1. Intellectual disability 1. Absence of perinatal risk factors
∗ Well-known genetic indicator; comparison with reference population was not possible because it was not reported in cerebral palsy literature.
332710
{332710:2T6EHQ2Z}
1
vancouver
50
default
7332
https://neuropediatoolkit.org/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%222T6EHQ2Z%22%2C%22library%22%3A%7B%22id%22%3A332710%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Janzing%20et%20al.%22%2C%22parsedDate%22%3A%222024-04-01%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EJanzing%20AM%2C%20Eklund%20E%2C%20De%20Koning%20TJ%2C%20Eggink%20H.%20Clinical%20Characteristics%20Suggestive%20of%20a%20Genetic%20Cause%20in%20Cerebral%20Palsy%3A%20A%20Systematic%20Review.%20Pediatric%20Neurology%20%5BInternet%5D.%202024%20Apr%201%20%5Bcited%202024%20May%2013%5D%3B153%3A144%26%23x2013%3B51.%20Available%20from%3A%20%3Ca%20class%3D%27zp-ItemURL%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS0887899424000389%27%3Ehttps%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS0887899424000389%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Clinical%20Characteristics%20Suggestive%20of%20a%20Genetic%20Cause%20in%20Cerebral%20Palsy%3A%20A%20Systematic%20Review%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anna%20M.%22%2C%22lastName%22%3A%22Janzing%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Erik%22%2C%22lastName%22%3A%22Eklund%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tom%20J.%22%2C%22lastName%22%3A%22De%20Koning%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hendriekje%22%2C%22lastName%22%3A%22Eggink%22%7D%5D%2C%22abstractNote%22%3A%22Background%5CnCerebral%20palsy%20%28CP%29%20is%20a%20clinical%20diagnosis%20and%20was%20long%20categorized%20as%20an%20acquired%20disorder%2C%20but%20more%20and%20more%20genetic%20etiologies%20are%20being%20identified.%20This%20review%20aims%20to%20identify%20the%20clinical%20characteristics%20that%20are%20associated%20with%20genetic%20CP%20to%20aid%20clinicians%20in%20selecting%20candidates%20for%20genetic%20testing.%5CnMethods%5CnThe%20PubMed%20database%20was%20systematically%20searched%20to%20identify%20genes%20associated%20with%20CP.%20The%20clinical%20characteristics%20accompanying%20these%20genetic%20forms%20of%20CP%20were%20compared%20with%20published%20data%20of%20large%20CP%20populations%20resulting%20in%20the%20identification%20of%20potential%20indicators%20of%20genetic%20CP.%5CnResullts%5CnOf%201930%20articles%20retrieved%2C%20134%20were%20included.%20In%20these%2C%2055%20CP%20genes%20%28described%20in%20two%20or%20more%20cases%2C%20n%5Cu00a0%3D%5Cu00a0272%29%20and%2079%20candidate%20genes%20%28described%20in%20only%20one%20case%29%20were%20reported.%20The%20most%20frequently%20CP-associated%20genes%20were%20PLP1%20%2821%20cases%29%2C%20ARG1%20%2817%20cases%29%2C%20and%20CTNNB1%20%2813%20cases%29.%20Dyskinesia%20and%20the%20absence%20of%20spasticity%20were%20identified%20as%20strong%20potential%20indicators%20of%20genetic%20CP.%20Presence%20of%20intellectual%20disability%2C%20no%20preterm%20birth%2C%20and%20no%20unilateral%20distribution%20of%20symptoms%20were%20classified%20as%20moderate%20genetic%20indicators.%5CnConclusions%5CnGenetic%20causes%20of%20CP%20are%20increasingly%20identified.%20The%20clinical%20characteristics%20associated%20with%20genetic%20CP%20can%20aid%20clinicians%20regarding%20to%20which%20individual%20with%20CP%20to%20offer%20genetic%20testing.%20The%20identified%20potential%20genetic%20indicators%20need%20to%20be%20validated%20in%20large%20CP%20cohorts%20but%20can%20provide%20the%20first%20step%20toward%20a%20diagnostic%20algorithm%20for%20genetic%20CP.%22%2C%22date%22%3A%222024-04-01%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.pediatrneurol.2024.01.025%22%2C%22ISSN%22%3A%220887-8994%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS0887899424000389%22%2C%22collections%22%3A%5B%22V3ZXX24J%22%5D%2C%22dateModified%22%3A%222024-05-13T10%3A10%3A28Z%22%7D%7D%5D%7D
Spanish 
English