332710
{332710:3N362ARW}
vancouver
50
3465
https://neuropediatoolkit.org/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-ec8b7de6168e4ebe7564215919d6bc9b%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%223N362ARW%22%2C%22library%22%3A%7B%22id%22%3A332710%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Janecka%20et%20al.%22%2C%22parsedDate%22%3A%222017-01%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EJanecka%20M%2C%20Mill%20J%2C%20Basson%20MA%2C%20Goriely%20A%2C%20Spiers%20H%2C%20Reichenberg%20A%2C%20et%20al.%20Advanced%20paternal%20age%20effects%20in%20neurodevelopmental%20disorders%26%23x2014%3Breview%20of%20potential%20underlying%20mechanisms.%20Translational%20Psychiatry%20%5BInternet%5D.%202017%20Jan%20%5Bcited%202018%20Mar%2020%5D%3B7%281%29%3Ae1019.%20Available%20from%3A%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Ftp2016294%27%3Ehttps%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Ftp2016294%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Advanced%20paternal%20age%20effects%20in%20neurodevelopmental%20disorders%5Cu2014review%20of%20potential%20underlying%20mechanisms%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Janecka%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Mill%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%20A.%22%2C%22lastName%22%3A%22Basson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Goriely%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H.%22%2C%22lastName%22%3A%22Spiers%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Reichenberg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Schalkwyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Fernandes%22%7D%5D%2C%22abstractNote%22%3A%22Multiple%20epidemiological%20studies%20suggest%20a%20relationship%20between%20advanced%20paternal%20age%20%28APA%29%20at%20conception%20and%20adverse%20neurodevelopmental%20outcomes%20in%20offspring%2C%20particularly%20with%20regard%20to%20increased%20risk%20for%20autism%20and%20schizophrenia.%20Conclusive%20evidence%20about%20how%20age-related%20changes%20in%20paternal%20gametes%2C%20or%20age-independent%20behavioral%20traits%20affect%20neural%20development%20is%20still%20lacking.%20Recent%20evidence%20suggests%20that%20the%20origins%20of%20APA%20effects%20are%20likely%20to%20be%20multidimensional%2C%20involving%20both%20inherited%20predisposition%20and%20de%20novo%20events.%20Here%20we%20provide%20a%20review%20of%20the%20epidemiological%20and%20molecular%20findings%20to%20date.%20Focusing%20on%20the%20latter%2C%20we%20present%20the%20evidence%20for%20genetic%20and%20epigenetic%20mechanisms%20underpinning%20the%20association%20between%20late%20fatherhood%20and%20disorder%20in%20offspring.%20We%20also%20discuss%20the%20limitations%20of%20the%20APA%20literature.%20We%20propose%20that%20different%20hypotheses%20relating%20to%20the%20origins%20of%20the%20APA%20effects%20are%20not%20mutually%20exclusive.%20Instead%2C%20multiple%20mechanisms%20likely%20contribute%2C%20reflecting%20the%20etiological%20complexity%20of%20neurodevelopmental%20disorders.%22%2C%22date%22%3A%222017-01%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Ftp.2016.294%22%2C%22ISSN%22%3A%222158-3188%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Ftp2016294%22%2C%22collections%22%3A%5B%22P6L7M587%22%5D%2C%22dateModified%22%3A%222018-03-20T17%3A40%3A39Z%22%7D%7D%5D%7D
1.
Janecka M, Mill J, Basson MA, Goriely A, Spiers H, Reichenberg A, et al. Advanced paternal age effects in neurodevelopmental disorders—review of potential underlying mechanisms. Translational Psychiatry [Internet]. 2017 Jan [cited 2018 Mar 20];7(1):e1019. Available from: https://www.nature.com/articles/tp2016294
Spanish 
English