332710
{332710:9AIZWFTV}
1
vancouver
50
default
7715
https://neuropediatoolkit.org/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%229AIZWFTV%22%2C%22library%22%3A%7B%22id%22%3A332710%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Auvin%20et%20al.%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EAuvin%20S%2C%20Arzimanoglou%20A%2C%20Falip%20M%2C%20Striano%20P%2C%20Cross%20JH.%20Refining%20management%20strategies%20for%20Lennox%26%23x2013%3BGastaut%20syndrome%3A%20Updated%20algorithms%20and%20practical%20approaches.%20Epilepsia%20Open%20%5BInternet%5D.%20%5Bcited%202025%20Jan%209%5D%3Bn%5C%2Fa%28n%5C%2Fa%29.%20Available%20from%3A%20%3Ca%20class%3D%27zp-ItemURL%27%20href%3D%27https%3A%5C%2F%5C%2Fonlinelibrary.wiley.com%5C%2Fdoi%5C%2Fabs%5C%2F10.1002%5C%2Fepi4.13075%27%3Ehttps%3A%5C%2F%5C%2Fonlinelibrary.wiley.com%5C%2Fdoi%5C%2Fabs%5C%2F10.1002%5C%2Fepi4.13075%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Refining%20management%20strategies%20for%20Lennox%5Cu2013Gastaut%20syndrome%3A%20Updated%20algorithms%20and%20practical%20approaches%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22St%5Cu00e9phane%22%2C%22lastName%22%3A%22Auvin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexis%22%2C%22lastName%22%3A%22Arzimanoglou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Merc%5Cu00e8%22%2C%22lastName%22%3A%22Falip%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pasquale%22%2C%22lastName%22%3A%22Striano%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20Helen%22%2C%22lastName%22%3A%22Cross%22%7D%5D%2C%22abstractNote%22%3A%22Lennox%5Cu2013Gastaut%20syndrome%20%28LGS%29%20is%20a%20severe%20developmental%20and%20epileptic%20encephalopathy%20%28DEE%29%20characterized%20by%20multiple%20types%20of%20drug-resistant%20seizures%20%28which%20must%20include%20tonic%20seizures%29%20with%20classical%20onset%20before%208%20years%20%28although%20some%20cases%20with%20later%20onset%20have%20also%20been%20described%29%2C%20abnormal%20electroencephalographic%20features%2C%20and%20cognitive%20and%20behavioral%20impairments.%20Management%20and%20treatment%20of%20LGS%20are%20challenging%2C%20due%20to%20associated%20comorbidities%20and%20the%20treatment%20resistance%20of%20seizures.%20A%20panel%20of%20five%20epileptologists%20reconvened%20to%20provide%20updated%20guidance%20and%20treatment%20algorithms%20for%20LGS%2C%20incorporating%20recent%20advancements%20in%20antiseizure%20medications%20%28ASMs%29%20and%20understanding%20of%20DEEs.%20The%20resulting%20consensus%20document%20is%20based%20on%20current%20evidence%20from%20clinical%20trials%20and%20clinical%20practice%20and%20the%20panel%27s%20expert%20opinion%2C%20focusing%20on%20new%20ASMs%20with%20novel%20mechanisms%20of%20action%2C%20such%20as%20highly%20purified%20cannabidiol%20and%20fenfluramine.%20For%20a%20patient%20presenting%20with%20newly%20diagnosed%20LGS%20or%20suspected%20LGS%2C%20the%20recommended%20first-line%20treatment%20continues%20to%20be%20valproate.%20If%20this%20is%20ineffective%20as%20monotherapy%2C%20adjunctive%20therapy%20with%2C%20firstly%2C%20lamotrigine%20and%20secondly%2C%20rufinamide%2C%20is%20recommended.%20If%20seizure%20control%20remains%20suboptimal%2C%20subsequent%20adjunctive%20ASM%20treatment%20options%20include%20%28alphabetically%29%20cannabidiol%2C%20clobazam%2C%20felbamate%2C%20fenfluramine%2C%20and%20topiramate%2C%20although%20evidence%20for%20these%20is%20more%20limited.%20Whenever%20possible%2C%20no%20more%20than%20two%20ASMs%20should%20be%20used%20together.%20Nonpharmacological%20treatment%20approaches%20should%20be%20used%20in%20conjunction%20with%20ASM%20therapy%20and%20include%20ketogenic%20diet%20therapies%2C%20vagus%20nerve%20stimulation%2C%20and%20corpus%20callosotomy.%20Patients%20with%20LGS%20that%20has%20evolved%20from%20another%20type%20of%20epilepsy%20who%20are%20not%20already%20being%20treated%20with%20valproate%20should%20be%20transitioned%20to%20valproate%20and%20then%20managed%20using%20the%20same%20algorithm%20as%20for%20newly%20diagnosed%20LGS.%20Older%20patients%20with%20established%20LGS%20should%20be%20reviewed%20at%20least%20annually%20by%20a%20suitably%20experienced%20neurologist.%20The%20revised%20guidance%20aims%20to%20improve%20seizure%20control%20and%20quality%20of%20life%20for%20patients%20with%20LGS%20through%20personalized%2C%20evidence-based%20treatment%20strategies%20while%20addressing%20the%20challenges%20of%20accurate%20diagnosis%20and%20management%20in%20a%20rapidly%20evolving%20therapeutic%20landscape.%20Plain%20Language%20Summary%20Lennox%5Cu2013Gastaut%20syndrome%20%28LGS%29%20is%20a%20severe%20type%20of%20epilepsy%20that%20usually%20starts%20in%20childhood%20but%20continues%20into%20adulthood.%20It%20is%20characterized%20by%20a%20variety%20of%20different%20types%20of%20seizures%20%28abnormal%20electrical%20activity%20in%20the%20brain%29%2C%20which%20are%20difficult%20to%20treat%20and%20often%20cause%20people%20with%20the%20condition%20to%20fall%20and%20injure%20themselves.%20Most%20people%20with%20LGS%20have%20learning%20difficulties%20and%20need%20a%20lot%20of%20support%2C%20often%20in%20residential%20care.%20The%20authors%20are%20experts%20in%20treating%20people%20with%20LGS%20and%20this%20article%20provides%20up-to-date%20guidance%20and%20advice%20on%20how%20best%20to%20care%20for%20those%20with%20the%20condition.%22%2C%22date%22%3A%22%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1002%5C%2Fepi4.13075%22%2C%22ISSN%22%3A%222470-9239%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fonlinelibrary.wiley.com%5C%2Fdoi%5C%2Fabs%5C%2F10.1002%5C%2Fepi4.13075%22%2C%22collections%22%3A%5B%22E8U5N6TS%22%5D%2C%22dateModified%22%3A%222025-01-09T18%3A15%3A27Z%22%7D%7D%5D%7D
1.
Auvin S, Arzimanoglou A, Falip M, Striano P, Cross JH. Refining management strategies for Lennox–Gastaut syndrome: Updated algorithms and practical approaches. Epilepsia Open [Internet]. [cited 2025 Jan 9];n/a(n/a). Available from: https://onlinelibrary.wiley.com/doi/abs/10.1002/epi4.13075
English 
Spanish