Mechanisms of Action of Antiepileptic Treatments Antiepileptic treatments (AED) are essential for the control of chronic pain associated with epileptic seizures. These medications act through various mechanisms that may vary depending on the type of AED used. Understanding these mechanisms is crucial for their correct use and management in pediatric patients. …
Category archives: Epilepsy
KCNx databases.
KCNx Databases: An Essential Tool for the Diagnosis and Management of Neurological Disorders in Childhood The KCNx Database represents one of the most advanced and specialized platforms in the field of pediatric neurogenetics, designed specifically to integrate and organize multidimensional data on potassium channels of the KCNx type (K+ channel, voltage-gated, subfamily...
Misinterpretation of wicket spikes.
Among the multiple patterns that we can find in EEG waves, one of the most intriguing is wicked spikes. These peculiar formations are important when it comes to understanding brain functioning, but they can also lead to misinterpretation, particularly when they are confused with juxtaposed epileptiform activity. The wicked spikes, also known as…
ARX gen.
The ARX (Aristaless-related homeobox) gene, located on chromosome Molecular Basis and Pathogenic Mechanisms The ARX protein contains a…
Panayitopoulos
Panayiotopoulos Syndrome (Benign Occipital Epilepsy of Childhood) Panayiotopoulos syndrome is a common benign idiopathic focal epilepsy of childhood that typically presents between 3 and 6 years of age. Main Characteristics Autonomic crises: The crises consist predominantly of autonomic symptoms such as nausea, emetic vomiting, paleness, mydriasis and incontinence. Duration …
Dravet syndrome. Natural history.
Dravet Syndrome: Natural History and Clinical Evolution in Multidimensional Perspective Dravet Syndrome (DS), initially described as a myoclonic epilepsy of childhood, is today recognized as one of the most severe forms of early-onset epilepsy with epileptic encephalopathy (DEE). Its natural history is complex, progressive…
Pharmacological treatment protocol for GLS.
Protocolo de Tratamiento Farmacológico del Síndrome de Lennox-Gastaut: Enfoque Integral y Basado en Evidencia El Síndrome de Lennox-Gastaut (SLG) representa una de las formas más severas y complejas de epilepsia en la infancia, clasificada como un encefalopatía epiléptica desarrollamental (DEE) de inicio temprano, con una prevalencia estimada entre 1 y 3 casos por 100,000 niños. …
Continue reading «Protocolo de tratamiento farmacológico del SLG.»
Precision medicine in genetic epilepsy.
Precision Medicine in Genetic Epilepsy and Developmental Encephalopathies (DEEs) Precision medicine in neurodevelopmental and epileptic encephalopathies (DEEs) seeks to direct pharmacological treatment towards the pathophysiological and molecular mechanism underlying the patient's genetic variant, avoiding ineffective or harmful therapies. Clinical Breakdown of Therapeutic Approaches Represented Below…
Continue reading «Medicina de precisión en epilepsia genética.»
SCNx database.
SCNx Database: A Rigorous Clinical Guide SCN Portal is an online database developed by the Broad Institute that provides information on the genetics and biology of sleep. This tool is valuable to medical professionals, especially neuropediatricians, as it offers a detailed resource on the spectrum of disorders…
