19955111
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statussuccessupdateneededfalseinstancefalsemetarequest_last0request_next%2 20used_cachetruedatakeyBU K8GQSElibraryid19955111meta%2 2creatorSummaryJaneckaetal.parsedDate2017-01numChildren1bibltdivclass%3 Dquotcsl-bib-bodyquotstylequotline-height1.35quotgtnltdivclassquotcsl-en tryquotstylequotclearleftquotgtnltdivclassquotcsl-left-marginquot stylequotfloatleftpadding-right0.5emtext-alignrightwidth1emquotgt1.lt divgtltdivclassquotcsl-right-inlinequotstylequotmargin0.4em01.5emquotgt JaneckaMMillJBassonMAGorielyASpiersHReichenbergAetal.Advancedpaternalageeffect sinneurodevelopmentaldisordersx2014reviewofpotentialunderlyingmechanisms.TranslationalPsychiatryInternet .2017Jancited2018Mar2071e1019.A vailablefromltaclass039zp-ItemURL039%3 Bhref039httpswww.nature.comarticlestp2016294039gthttpswww.nature.com articlestp2016294ltagtltdivgt%5 Cnltdivgtnltdivgtdat aitemTypejournalArticletitleAdvancedpaternalageeffectsinneurodevelopmentaldisordersu20 14reviewofpotentialunderlyingmechanismscreatorscreatorTypeauthorfirstNameM. lastNameJaneckacreatorTypeauthorfirstNameJ.lastNameMillcreator TypeauthorfirstNameM.A.lastNameBassoncreatorTypeauthorfirstName A.lastNameGorielycreatorTypeauthorfirstNameH.lastNameSpiers creatorTypeauthorfirstNameA.lastNameReichenbergcreatorTypeauthor%2 2firstNameL.lastNameSchalkwykcreatorTypeauthorfirstNameC.lastN ameFernandesabstractNoteMultipleepidemiologicalstudiessuggestarelationshipbetweenadvancedp aternalageAPAatconceptionandadverseneurodevelopmentaloutcomesinoffspringparticularlywithregardt oincreasedriskforautismandschizophrenia.Conclusiveevidenceabouthowage-relatedchangesinpaternalgametes% 2Corage-independentbehavioraltraitsaffectneuraldevelopmentisstilllacking.Recentevidencesuggeststhatth eoriginsofAPAeffectsarelikelytobemultidimensionalinvolvingbothinheritedpredispositionanddenovo%2 0events.Hereweprovideareviewoftheepidemiologicalandmolecularfindingstodate.Focusingonthelatter% 2Cwepresenttheevidenceforgeneticandepigeneticmechanismsunderpinningtheassociationbetweenlatefatherhood anddisorderinoffspring.WealsodiscussthelimitationsoftheAPAliterature.Weproposethatdifferenth ypothesesrelatingtotheoriginsoftheAPAeffectsarenotmutuallyexclusive.Insteadmultiplemechanismslik elycontributereflectingtheetiologicalcomplexityofneurodevelopmentaldisorders.date2017-01sect ionpartNumberpartTitle DOI10.1038tp.2016.294citationKey urlhttpswww.nature.comarticlestp20 16294PMIDPMCIDISSN21 58-3188languageencollectionsSAEU5R AXdateModified2026-05-09T213700Z
1.
Janecka M, Mill J, Basson MA, Goriely A, Spiers H, Reichenberg A, et al. Advanced paternal age effects in neurodevelopmental disorders—review of potential underlying mechanisms. Translational Psychiatry [Internet]. 2017 Jan [cited 2018 Mar 20];7(1):e1019. Available from: https://www.nature.com/articles/tp2016294