19955111
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vancouver
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statussuccessupdateneededfalseinstancefalse%2 2metarequest_last0request_next0used_cachetrue% 2CdatakeyDMWLVJBClibraryid19955111 metacreatorSummaryNikitinaetal.parsedDate%2 22021-02-22numChildren1bibltdivclassquot%3 Bcsl-bib-bodyquotstylequotline-height1.35quotgt%5 Cnltdivclassquotcsl-entryquotstylequotclear leftquotgtnltdivclassquotcsl-left-margin quotstylequotfloatleftpadding-right0.5emtext-ali gnrightwidth1emquotgt1.ltdivgtltdi vclassquotcsl-right-inlinequotstylequotmargin0.4em%2 001.5emquotgtNikitinaTVKashevarovaAAGridinaMML opatkinaMEKhabarovaAAYakovlevaYSetal.Complexbiologyofconstitutionalringchromosomesstructureandinstabilityrevealed%2 0bysomaticcellreprogramming.SciRepInternet.2021Feb22 cited2023Mar121114325.Availablefromltaclass 039zp-ItemURL039href039httpswww.nature.com articless41598-021-83399-3039gthttpswww.nature.co marticless41598-021-83399-3ltagtltdivgtn ltdivgtnltdivgtdataitemTy pejournalArticletitleComplexbiologyofconstitutionalringchromosomesstructureandinstabilityrevealedbysomaticcell%2 0reprogrammingcreatorscreatorTypeauthorfirstName% 22T.V.lastNameNikitinacreatorTypeauthor% 22firstNameA.A.lastNameKashevarovacreat orTypeauthorfirstNameM.M.lastNameGridina creatorTypeauthorfirstNameM.E.lastName%2 2LopatkinacreatorTypeauthorfirstNameA.A. lastNameKhabarovacreatorTypeauthorfirstN ameYuS.lastNameYakovlevacreatorTypeau thorfirstNameA.G.lastNameMenzorovcrea torTypeauthorfirstNameYuA.lastNamePussy creatorTypeauthorfirstNameI.E.lastName% 22PristyazhnyukcreatorTypeauthorfirstNameS. A.lastNameVasilyevcreatorTypeauthorfi rstNameD.A.lastNameFedotovcreatorType authorfirstNameO.L.lastNameSerovcrea torTypeauthorfirstNameI.N.lastNameLebedev%2 2abstractNoteHumanringchromosomesareoftenunstableduringmitosisanddaughtercellscanbepartiallyorcompletelyaneupl oid.Westudiedthemitoticstabilityoffourringchromosomes8 1318and22inlong-termculturesofskinfibroblastsand% 20inducedpluripotentstemcellsiPSCsbyGTGkaryotypingandaCGH.Ringchromosomelossandsecondaryaberrationswereobservedinall fibroblastculturesexceptforr18.Wefoundmonosomyfragmentationandtranslocationofindexedchromosomes.IniPSCsaCGHrevealed strikingdifferencesinmitoticstabilitybothbetweeniPSClineswithdifferentringsandinsomecasesbetweencelllineswiththe% 20sameringchromosome.Weregisteredthespontaneousrescueofkaryotyp e46XYr8to46XYinallsixiPSClinesthroughringch romosomelossandintacthomologueduplicationwithisoUPD8patoccurrenceasprovenbySNPgenotypedistributionanalysis.IniPSCswith% 20otherringchromosomeskaryotypecorrectionwasnotobserved.Ourresultssuggestthatspontaneouscorrectionofthekaryotypewithringc hromosomesiniPSCsisnotuniversalandthatpluripotencyiscompatiblewithawiderangeofderivativekaryotypes.Weconcludethatmarked variabilityinthefrequencyofsecondaryrearrangementsexistsinbothfibroblastandiPSCculturesexpandingtheclinicalsignificanceof theconstitutionalringchromosome.date2021-02-22sectio npartNumberpartTitleDOI10.10 38s41598-021-83399-3citationKeyurlhttps% 5Cwww.nature.comarticless41598-021-83399-3PMIDPMC IDISSN2045-2322languageencollections% 223R7HGPJKdateModified2026-05-09T071846Z
1.
Nikitina TV, Kashevarova AA, Gridina MM, Lopatkina ME, Khabarova AA, Yakovleva YS, et al. Complex biology of constitutional ring chromosomes structure and (in)stability revealed by somatic cell reprogramming. Sci Rep [Internet]. 2021 Feb 22 [cited 2023 Mar 12];11(1):4325. Available from: https://www.nature.com/articles/s41598-021-83399-3