The main identifiable risk factor in the medical history is the presence of an older sibling with ASD, such that 1 in 5 children with older siblings with ASD will have a diagnosis of ASD at 3 years of age, being more frequent among males.
Another risk factor is parental age at the time of conception.
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statussuccessupdateneededfalseinstancefalsemeta%3 Arequest_last0request_next0used_cachetruedata%7 Bkey7MK7GWZJlibraryid19955111metacreator SummaryOzonoffetal.parsedDate2011-09numChildren2%2 Cbibltdivclassquotcsl-bib-bodyquotstylequotline-heig ht1.35quotgtnltdivclassquotcsl-entryquots tylequotclearleftquotgtnltdivclassquot csl-left-marginquotstylequotfloatleftpadding-right0.5emt ext-alignrightwidth1emquotgt1.ltdivgtltdiv% 20classquotcsl-right-inlinequotstylequotmargin0.4em01.5em%3 BquotgtOzonoffSYoungGSCarterAMessingerDYirmiyaN ZwaigenbaumLetal.RecurrenceRiskforAutismSpectrumDisordersAB abySiblingsResearchConsortiumStudy.PediatricsInternet.2011Septci ted2022Oct101283e488x201395.Availablefromltacla ss039zp-ItemURL039href039httpswww.ncbi.nlm.nih.gov pmcarticlesPMC3164092039gthttpswww.ncbi.nlm.nih .govpmcarticlesPMC3164092ltagtltdivgt nltdivgtnltdivgtdataitemType% 22journalArticletitleRecurrenceRiskforAutismSpectrumDisordersA BabySiblingsResearchConsortiumStudycreatorscreatorType%2 2authorfirstNameSallylastNameOzonoffcreatorType%2 2authorfirstNameGregoryS.lastNameYoungcre atorTypeauthorfirstNameAlicelastNameCarter%2 2creatorTypeauthorfirstNameDaniellastNameMessinger creatorTypeauthorfirstNameNuritlastNameYirmiya creatorTypeauthorfirstNameLonnielastNameZ waigenbaumcreatorTypeauthorfirstNameSusanlastName% 22BrysoncreatorTypeauthorfirstNameLeslieJ.%2 2lastNameCarvercreatorTypeauthorfirstNameJohnN .lastNameConstantinecreatorTypeauthorfirstName% 3AKarenlastNameDobkinscreatorTypeauthorfirstNam eTedlastNameHutmancreatorTypeauthorfirstN ameJanaM.lastNameIversoncreatorTypeauthor%2 CfirstNameRebeccalastNameLandacreatorTypeauthor firstNameSallyJ.lastNameRogerscreatorType%3 AauthorfirstNameMarianlastNameSigmancreatorType authorfirstNameWendyL.lastNameStoneab stractNoteOBJECTIVEnTherecurrenceriskofautismspectrumdisorders ASDisestimatedtobebetween3and10butpreviousresearchwas limitedbysmallsamplesizesandbiasesrelatedtoascertainmentreporting andstoppagefactors.Thisstudyusedprospectivemethodstoobtainanu pdatedestimateofsiblingrecurrenceriskforASD.nnMETHODSnAprospectiv elongitudinalstudyofinfantsatriskforASDwasconductedbyamultisit einternationalnetworktheBabySiblingsResearchConsortium.Infantsn%3 D664withanolderbiologicalsiblingwithASDwerefollowedfromearly% 20inlifeto36monthswhentheywereclassifiedashavingornothaving ASD.AnASDclassificationrequiredsurpassingthecutoffoftheAutismDiagnosticObservationScheduleandreceivingaclinicaldiagnosisfromanexpertc linician.nnRESULTSnAtotalof18.7oftheinfantsdevelopedASD.In fantgenderandthepresenceofgt1olderaffectedsiblingweremeans ntpredictorsofASDoutcomeandtherewasanalmostthreefoldincreasein riskformalesubjectsandanadditionaltwofoldincreaseinriskifthere wasgt1olderaffectedsibling.Theageoftheinfantatstudyenro llmentthegenderandfunctioningleveloftheinfant039soldersibli ngandotherdemographicfactorsdidnotpredictASDoutcome.nnCONCLUSIONS nThesiblingrecurrencerateofASDishigherthansuggestedbyprevious% 20estimates.Thesizeofthecurrentsampleandprospectivenatureofdatacollectionminimizedmanylimitationsofpreviousstudiesofsiblingrecurrence.C linicalimplicationsincludinggeneticcounselingarediscussed.date 2011-9sectionpartNumberpartTitleDOI 10.1542peds.2010-2825citationKeyurlhttps www.ncbi.nlm.nih.govpmcarticlesPMC3164092PMID21844053 PMCIDPMC3164092ISSN0031-4005languageco collectionsJS3DPJ2QdateModified2026-05-09T055948Z
1.
Ozonoff S, Young GS, Carter A, Messinger D, Yirmiya N, Zwaigenbaum L, et al. Recurrence Risk for Autism Spectrum Disorders: A Baby Siblings Research Consortium Study. Pediatrics [Internet]. 2011 Sept [cited 2022 Oct 10];128(3):e488–95. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164092/
