¿Para qué sirven las distintas tecnologías genéticas? ¿Que tipo de mutaciones es capaz de detectar cada técnica? 332710 {332710:9S39TT29} vancouver 50 2470 https://neuropediatoolkit.org/wp-content/plugins/zotpress/ %7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-9e617efaba6ecfaf06e5e4fc51b1a346%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%229S39TT29%22%2C%22library%22%3A%7B%22id%22%3A332710%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Katsanis%20and%20Katsanis%22%2C%22parsedDate%22%3A%222013-06%22%2C%22numChildren%22%3A4%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EKatsanis%20SH%2C%20Katsanis%20N.%20Molecular%20genetic%20testing%20and%20the%20future%20of%20clinical%20genomics.%20Nat%20Rev%20Genet%20%5BInternet%5D.%202013%20Jun%20%5Bcited%202015%20Apr%2027%5D%3B14%286%29%3A415%26%23x2013%3B26.%20Available%20from%3A%20%3Ca%20href%3D%27http%3A%5C%2F%5C%2Fwww.nature.com%5C%2Fnrg%5C%2Fjournal%5C%2Fv14%5C%2Fn6%5C%2Ffull%5C%2Fnrg3493.html%27%3Ehttp%3A%5C%2F%5C%2Fwww.nature.com%5C%2Fnrg%5C%2Fjournal%5C%2Fv14%5C%2Fn6%5C%2Ffull%5C%2Fnrg3493.html%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Molecular%20genetic%20testing%20and%20the%20future%20of%20clinical%20genomics.%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sara%20Huston%22%2C%22lastName%22%3A%22Katsanis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicholas%22%2C%22lastName%22%3A%22Katsanis%22%7D%5D%2C%22abstractNote%22%3A%22Genomic%20technologies%20are%20reaching%20the%20point%20of%20being%20able%20to%20detect%20genetic%20variation%20in%20patients%20at%20high%20accuracy%20and%20reduced%20cost%2C%20offering%20the%20promise%20of%20fundamentally%20altering%20medicine.%20Still%2C%20although%20scientists%20and%20policy%20advisers%20grapple%20with%20how%20to%20interpret%20and%20how%20to%20handle%20the%20onslaught%20and%20ambiguity%20of%20genome-wide%20data%2C%20established%20and%20well-validated%20molecular%20technologies%20continue%20to%20have%20an%20important%20role%2C%20especially%20in%20regions%20of%20the%20world%20that%20have%20more%20limited%20access%20to%20next-generation%20sequencing%20capabilities.%20Here%20we%20review%20the%20range%20of%20methods%20currently%20available%20in%20a%20clinical%20setting%20as%20well%20as%20emerging%20approaches%20in%20clinical%20molecular%20diagnostics.%20In%20parallel%2C%20we%20outline%20implementation%20challenges%20that%20will%20be%20necessary%20to%20address%20to%20ensure%20the%20future%20of%20genetic%20medicine.%22%2C%22date%22%3A%22Junio%202013%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fnrg3493%22%2C%22ISSN%22%3A%221471-0056%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fwww.nature.com%5C%2Fnrg%5C%2Fjournal%5C%2Fv14%5C%2Fn6%5C%2Ffull%5C%2Fnrg3493.html%22%2C%22collections%22%3A%5B%227BFFA6NH%22%2C%227XAESF88%22%5D%2C%22dateModified%22%3A%222016-09-06T17%3A15%3A59Z%22%7D%7D%5D%7D 1.Katsanis SH, Katsanis N. Molecular genetic testing and the future of clinical genomics. Nat Rev Genet [Internet]. 2013 Jun [cited 2015 Apr 27];14(6):415–26. Available from: http://www.nature.com/nrg/journal/v14/n6/full/nrg3493.html