https://www.frontiersin.org/articles/10.3389/fnins.2023.1188839/full
https://www.aeped.es/comite-medicamentos/pediamecum/coenzima-q10-ubidecarenona
Indications for treatment in pediatric neurology:
- Mitochondrial diseases:
- Congenital coenzyme Q10 deficiency (primary). Symptoms in the form of cerebellar ataxia, encephalomyopathy, isolated myopathy.
- Other mitochondrial diseases (secondary deficiency):
- Friedrich's ataxia.
- CPEO (Chronic Progressive External Ophthalmoplegia),
- Mitochondrial complex I deficiency.
- Mitochondrial complex II deficiency.
- Mitochondrial complex II/IV deficiency.
- Kearns-Sayre syndrome.
- LHON (Leber's Hereditary Optic Neuropathy).
- MELAS (Mitochondrial myopathy, Encephalopathy, Lactic Acidosis and Stroke-like).
- NARP (Neurogenic muscle weakness, Ataxia, and Retinitis Pigmentosa).
- Twinkle disorders (C10orf2)
- Oculomotor apraxia.
- Mitochondrial cardiomyopathy.
- Alpers disease.
- MERRF (Myoclonic Epilepsy associated with Ragged Red Fibers).
- SANDO (Sensory Ataxia with Neuropathy, Dysarthria and Ophthalmoparesis)
- Mitochondrial DNA depletion syndrome.
- Other diseases (secondary deficiency):
- Propionic acidemia.
- Multiple system atrophy.
- Corticobasal degeneration.
- Muscular dystrophy.
- Amyotrophic lateral sclerosis.
- Multiple sclerosis.
- Charcot-Marie-Tooth disease.
- McArdle disease.
- Leukodystrophy.
- Migraine.
- Myopathy due to myoadenylate deaminase (MADA) deficiency.
- Progressive supranuclear palsy.
- Cyclic vomiting syndrome.
- Sanfilippo syndrome.
- Wolf-Hirschhorn syndrome.
- Bardet-Biedl syndrome.
- Chronic fatigue syndrome.
- Stroke.
- Adrenoleukodystrophy.
- Spinocerebellar ataxia.
- Folic acid deficiency.
- Oculopharyngeal dystrophy.
- Steinert myotonic dystrophy.
- Huntington's disease.
- Niemann-Pick disease.
- Pompe disease.
- Spasticity.
- Spastic paraparesis.
- Prader-Willi syndrome.
- Wolfram syndrome.