19955111
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https://neuropediatoolkit.org/wp-content/plugins/zotpress/
statussuccessupdateneededfalseinstancefalsemetarequest_last0request_next0used_cache truedatakeyNMMWTEGDlibrary id19955111metacreatorSummaryHorberetal. parsedDate2021-02-09numChildren1bib ltdivclassquotcsl-bib-bodyquotstylequotline-h eight1.35quotgtnltdivclassquotcsl -entryquotstylequotclearleftquotgtn% 20ltdivclassquotcsl-left-marginquotstylequotfloatleftpadding-right0.5emtext-alignrightwid th1emquotgt1.ltdivgtltdivclass quotcsl-right-inlinequotstylequotmargin0.4em01.5 emquotgtHorberVGrasshoffUSellierEArnaud%2 0CKrxE4geloh-MannIHimmelmannK.TheRoleofNeuroi magingandGeneticAnalysisintheDiagnosisofChildrenWithCerebralPalsy.FrontNeurolInternet.2021Feb9cited202 6Jan411.Availablefromltaclass039zp-Ite mURL039href039httpswww.frontiersin.orgj ournalsneurologyarticles10.3389fneur.2020.628075full%2 6039gthttpswww.frontiersin.orgjournalsneurolo gyarticles10.3389fneur.2020.628075fullltagt% 3Bltdivgtnltdivgtnltdiv% 26gtdataitemTypejournalArticletitleTheRoleofNeuroimagingandGeneticAnalysisintheDiagnosis%2 0ofChildrenWithCerebralPalsycreatorscreatorTypeauthorfirstNameVeronkalastNameHorber creatorTypeauthorfirstNameUtelastNam eGrasshoffcreatorTypeauthorfirstName ElodielastNameSelliercreatorTypeauthor firstNameCatherinelastNameArnaudc reatorTypeauthorfirstNameIngeborglastNameKru00e4geloh-ManncreatorTypeauthorfirstName KatelastNameHimmelmannabstractNoteCerebralmagneticresonanceimagingMRIisconsideredanimport anttoolintheassessmentofachildwithcerebralpalsyCPasitisabnormalinmorethan80ofchildrenwith% 20CPdisclosingthepathogenicpatternresponsiblefortheneurologicalcondition.MRIthereforeisrecommendedasthefirst%2 0diagnosticstepaftermedicalhistorytakingandneurologicalexamination.Withtheadvancesingeneticdiagnosticsthegeneticcontr ibutiontoCPisincreasinglydiscussedandthequestionarisesabouttheroleofgenetictestinginthediagnosisofcerebral% 20palsy.ThepapergivesanoverviewongeneticfindingsreportedinCPwhicharediscussedwithrespecttotheunderlyingbr ainpathologyaccordingtoneuroimagingfindings.SurveillanceofCerebralPalsyinEuropeSCPEclassifiesneuroimagingfindingsin% 20CPintofivecategorieswhichhelptostratifydecisionsconcerninggenetictesting.Predominantwhiteandgreymatterinjuries%2 0arebyfarpredominantaccountingforaround50and20offindings.Theyareconsideredtobeacquired.Herepred isposinggeneticfactorsmayplayaroletoincreasevulnerabilityandshouldespeciallybeconsideredwhenfamilyhistoryis% 20positiveandorcausativeexternalfactorsaremissing.Inmaldevelopmentsandnormalfindingsaround11eachmonog eniccausesaremorelikelyandthusgenetictestingisclearlyrecommended.Inthemiscellaneouscategorytheprecisenature% 20oftheMRIfindinghastobeconsideredasitcouldindicat eageneticorigin.date2021-02-09section%2 2partNumberpartTitleDOI10.3389 fneur.2020.628075citationKeyurlhttps www.frontiersin.orgjournalsneurologyarticles10.3389%5 Cfneur.2020.628075fullPMIDPMCID%2 2ISSN1664-2295languageEnglishcollections%5 BD3GNDRTBdateModified2026-05-09T062547Z
1.
Horber V, Grasshoff U, Sellier E, Arnaud C, Krägeloh-Mann I, Himmelmann K. The Role of Neuroimaging and Genetic Analysis in the Diagnosis of Children With Cerebral Palsy. Front Neurol [Internet]. 2021 Feb 9 [cited 2026 Jan 4];11. Available from: https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2020.628075/full