The Error checking for updates It is the degree of blood relationship between two people (kinship). There are various degrees of consanguinity. It is a risk factor for genetic diseases, particularly autosomal recessive (¿when to suspect a metabolism, above all, those that have curative treatment?).
coefficient of inbreeding, inbreeding coefficient
There is a coefficient of inbreeding and coefficient of relationship), which allows calculating the probability of homozygosity based on ancestry, or inferring the presence of consanguinity from the degree of homozygosity, which can be identified in the SNP arrays (runs of homozygosity). This can lead to the unmasking of incestuous and abusive relationships.
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Schaaf C, Scott D, Wiszniewska J, Beaudet A. Identification of incestuous parental relationships by SNP-based DNA microarrays. The Lancet [Internet]. 2011 [cited 2021 Apr 18];377(9765):555–6. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0140673611602018
Countries with more consanguinity.
Consanguinity is higher in those countries that practice inbreeding. The result is an increase in homozygosity, and as a consequence, a higher prevalence of diseases. autosomal recessive.
The regions of homozygosity (ROH) are the genetic result of consanguinity, and can be studied using genetic techniques such as the SNP array. The inbreeding coefficient is directly correlated with the number of homozygosity tracts in a genome.
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Consanguinity in European royal families.
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