Le consanguinité Il est le degré de relation génétique entre deux personnes (parenté). Il existe différents degrés de consanguinité. C'est un facteur de risque pour les maladies génétiques, en particulier les récessive autosomique (¿Quand vous soupçonnez une métabolopathie, en particulier, celles qui ont traitement curatif?).
Coefficient de consanguinité.
Il existe un coefficient d'endogamie (coefficient d'inbreeding et coefficent de relation), qui permet de calculer la probabilité d'homozygotie en fonction de l'ascendance, ou de déduire la présence de consanguinité à partir du degré d'homozygotie, qui peut être identifié dans les tableaux SNP (séries d'homozygotie). Cela peut conduire à démasquer des relations incestueuses et abusives.
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Schaaf C, Scott D, Wiszniewska J, Beaudet A. Identification des relations parentales incestueuses par des puces à ADN basées sur SNP. Le Lancet [Internet]. 2011 [cité le 18 avril 2021];377(9765):555-6. Disponible à partir de : https://linkinghub.elsevier.com/retrieve/pii/S0140673611602018
Pays avec plus de consanguinité.
La consanguinidad est plus élevée dans les pays qui pratiquent la consanguinitéLe résultat est une augmentation de la homocigotoxie, et en conséquence, une plus grande prévalence de maladies. récessive autosomique.
Les régions d'homozygotie (ROH) sont le résultat génétique de la consanguinité et peuvent être étudiées à l'aide de techniques génétiques telles que la matrice SNP. Le coefficient de consanguinité est directement corrélé au nombre de zones d'homozygotie dans un génome.
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La consanguinité dans les familles royales européennes.
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1.
Alvarez G, Ceballos FC, Quinteiro C. Le rôle de la consanguinité dans l'extinction d'une dynastie royale européenne. Bauchet M, éditeur. PLOS Un [Internet]. 15 avril 2009 [cité le 22 mars 2026];4(4):e5174. Disponible à partir de : https://dx.plos.org/10.1371/journal.pone.0005174
