Der Blutsverwandtschaft Dabei handelt es sich um den Grad der Blutsverwandtschaft zwischen zwei Menschen (Verwandtschaft). Es gibt verschiedene Grade der Blutsverwandtschaft. Es ist insbesondere ein Risikofaktor für genetisch bedingte Erkrankungen autosomal-rezessiv (¿wann man einen Stoffwechsel vermutet, vor allem diejenigen, die es haben Heilbehandlung?).
Inzuchtkoeffizient.
Es gibt einen Inzuchtkoeffizienten und Beziehungskoeffizient), was es ermöglicht, die Wahrscheinlichkeit einer Homozygotie basierend auf der Abstammung zu berechnen oder aus dem Grad der Homozygotie, der in den SNP-Arrays (Läufe der Homozygotie) identifiziert werden kann, auf das Vorliegen einer Blutsverwandtschaft zu schließen. Dies kann zur Aufdeckung inzestuöser und missbräuchlicher Beziehungen führen.
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1.
Schaaf C, Scott D, Wiszniewska J, Beaudet A. Identifizierung inzestuöser elterlicher Beziehungen mittels SNP-basierter DNA-Microarrays. The Lancet [Internet]. 2011 [zitiert am 18. April 2021];377(9765):555–6. Verfügbar unter: https://linkinghub.elsevier.com/retrieve/pii/S0140673611602018
Länder mit mehr Blutsverwandtschaft.
In den Ländern, in denen dies praktiziert wird, ist die Blutsverwandtschaft größer Inzucht. Die Folge ist eine Zunahme der Homozygotie und in der Folge eine höhere Prävalenz von Krankheiten. autosomal-rezessiv.
Homozygotie-Regionen (Regions of Homozygosity, ROH) sind das genetische Ergebnis von Inzucht und können mithilfe genetischer Verfahren wie dem SNP-Array untersucht werden. Der Inzuchtkoeffizient steht in direktem Zusammenhang mit der Anzahl der Regionen der Homozygotie in einem Genom.
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1.
Sund KL, Zimmerman SL, Thomas C, Mitchell AL, Prada CE, Grote L, et al. Durch SNP-Microarray-Analyse identifizierte Homozygotie-Regionen unterstützen die Diagnose autosomal-rezessiver Erkrankungen und decken nebenbei Blutsverwandtschaftsverhältnisse zwischen den Eltern auf. Genet Med [Internet]. Januar 2013 [zitiert am 29. September 2016];15(1):70–8. Verfügbar unter: http://www.nature.com/gim/journal/v15/n1/full/gim201294a.html
Blutsverwandtschaft in europäischen Königsfamilien.
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1.
Alvarez G, Ceballos FC, Quinteiro C. Die Rolle der Inzucht beim Aussterben einer europäischen Königsfamilie. Bauchet M, Herausgeber. PLOS One [Internet]. 15. April 2009 [zitiert am 22. März 2026];4(4):e5174. Verfügbar unter: https://dx.plos.org/10.1371/journal.pone.0005174
