Sinaptopatías.

The comorbid diagnosis of ASD and ID requires that social communication be below what is expected for the general developmental level (Criterion E of DSM-5). The clinical differentiation between both entities in young children or those with severe disability is particularly complex, requiring a multidisciplinary approach and systematic phenotypic refinement.

CSWS

Continuous spike-wave during sleep is an age-dependent epileptic encephalopathy characterized by the presence of status epilepticus during deep sleep, and significant cognitive-behavioral consequences. It is also known as Penelope syndrome. Landau-Kleffner syndrome (or epilepsy-aphasia spectrum) is a subtype of this disease, in which the neurological deficit is …