Introduction Cerebro-renal syndromes constitute a heterogeneous group of entities in which central nervous system involvement and renal dysfunction coexist, either due to a common pathophysiological mechanism (defect of a metabolic pathway that affects both organs) or due to the pleiotropic expression of a gene that is critically expressed in the brain...
Category archives: Neurological diseases
Tropical infectious diseases during pregnancy.
Malaria during pregnancy: impact on fetal neurological development and prevention strategies Plasmodium falciparum infection during pregnancy represents one of the most significant obstetric complications in endemic regions, with far-reaching consequences that transcend the perinatal period and profoundly affect the neurological development of the child. The impact is not…
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Mechanisms in AED.
Mechanisms of Action of Antiepileptic Treatments Antiepileptic treatments (AED) are essential for the control of chronic pain associated with epileptic seizures. These medications act through various mechanisms that may vary depending on the type of AED used. Understanding these mechanisms is crucial for their correct use and management in pediatric patients. …
Scientific evidence in treatments for ADHD.
EBI-ADHD: Scientific evidence database for the treatment of ADHD https://ebiadhd-database.org/es The EBI-ADHD (Evidence-Based Interventions for ADHD) platform represents one of the most advanced and exhaustive tools for synthesizing scientific evidence in the field of Attention Deficit Hyperactivity Disorder (ADHD). More than a simple compilation of studies, it is…
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KCNx databases.
KCNx Databases: An Essential Tool for the Diagnosis and Management of Neurological Disorders in Childhood The KCNx Database represents one of the most advanced and specialized platforms in the field of pediatric neurogenetics, designed specifically to integrate and organize multidimensional data on potassium channels of the KCNx type (K+ channel, voltage-gated, subfamily...
Osteoporosis protocol (Galindo-Zavala):
Childhood osteoporosis is defined, in clinical practice, by the presence of fragility fractures. The International Society of Clinical Densitometry (ISCD), in its 2019 consensus, establishes two alternative conditions for the diagnosis [1,2]: Important: a Z-score > −2 does not exclude bone fragility or predisposition to fractures, especially in patients with pathologies that...
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Tasks to explore movement disorders.
Misinterpretation of wicket spikes.
Among the multiple patterns that we can find in EEG waves, one of the most intriguing is wicked spikes. These peculiar formations are important when it comes to understanding brain functioning, but they can also lead to misinterpretation, particularly when they are confused with juxtaposed epileptiform activity. The wicked spikes, also known as…
ARX gen.
The ARX (Aristaless-related homeobox) gene, located on chromosome Molecular Basis and Pathogenic Mechanisms The ARX protein contains a…
CdL facial phenotypes.
Facial Phenotypes in Cornelia de Lange Syndrome (CdLS) Cornelia de Lange syndrome (CdLS) is associated with a characteristic facial dysmorphic pattern that facilitates its clinical diagnosis: Synophridia: Very well-defined eyebrows, arched and united in the midline, along with unusually long eyelashes. Nasal anomalies: Short nose with depressed nasal bridge,…