Neuro-ophthalmological examination.

Neuro-ophthalmology is a complex field and usually there is no formal training. It sits between several specialties, making it difficult to determine the responsibilities of each professional. On the Neuro-ophthalmology at your fingertips website, there are educational videos on the neuroscience underlying neuro-ophthalmology. On the website of …

TR (tandem repeat) disorders.

1. Classification by unit size 2. Why they are unstable (common mechanism) Clinical consequence: genetic anticipation = phenotypic manifestation of this increasing meiotic instability (paternal or maternal bias depending on the disease). 3. Three mechanisms depending on the location of the repeat (STR block) A) Coding exon, triplets (CAG=polyQ) B) Non-coding region (UTR, intron), large expansion…

Notable mutations!

Notable Mutations Database This resource provides an up-to-date registry of pathogenic variants and genetic mutations that have relevant clinical impact or notable scientific interest in neuropediatrics and neurodevelopmental genetics. Includes detailed annotations on variants in ion channels (SCN1A, KCNQ2) and neuronal transporters with direct phenotypic correlation.